Yeon-su Jeon
Contents
Korean Genome Project & KOREF
Before class
SNP
single nucleotide polymorphism
DNA sequence variation within a population(1%) in which a single nucleotide in the genome.
Korean Genome Project
Korean genome project make goal that finds korean-only SNPs. Through this project(KPGP), 60000 SNPs were found as Korean unique SNP.
Most Koreans have mutation about protein associated with capsaicin, the spicy component in chili peppers, which feature heavily in Korean cuisine.
Difference between reference genome and re-sequenced genome
reference genome
Reference genome is the original model for representing the genome assemblies.
Reference genome is a digital nucleic acid sequence database, assembled by scientists as a representative example of a species' set of genes. Although reference genome don't accurately represent the set of genes of any single person, it provides a haploid mosaic of different DNA sequences from each donor.
Re-sequenced genome
When a reference genome already exist in their own species, resequenicng allows investigation of the relationship between sequence variation and normal or disease phenotypes.
What is KOREF?
KOREF means korean reference genome.
