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<p> </p>
<p>feature</p>
<ul>
<li>regulate gene expression : turn on / off </li>
<li>not part of a DNA sequence , but in some cases , they can be inherited to offspring</li>
<li>In general, methylation turn off the gene expression while acetylation turn on the gene expression</li>
</ul>
<p> </p>
<p>factorhistone modification</p>
<ul>
</ul>
</li>
</ul>
</li>
<li>DNA acetylation</li>
<li>DNA phosphorylation</li>
<li>DNA ubiquitination</li>
<li>SUMOylation</li>
<li>ADP-ribosylation</li>
<li>deamination</li>
</ul>
<p> </p>
<p>How to detect histone modification?</p>
<ul>
<li>Chip-Chip : chromatin immunoprecipitation with DNA microarrays
<ul>
<li>immunoprecipitation : specific antibodies are used to immunoprecipitate the DNA-histone complexes</li>
<li>visualization : purify immunoprecipitation --> amplification --> labeled with fluorescent tag</li>
</ul>
</li>
</ul>
<p> </p>
<hr />
<p>reference</p>
<p>1) https://en.wikipedia.org/wiki/Epigenomics</p>
<p>2) https://ghr.nlm.nih.gov/primer/howgeneswork/epigenome</p>
