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Created page with "<p>Epigenomics</p> <p> </p> <p>"Epi">>reversible</p> <p> </p> <p>definition : modifications on DNA /histones</p> <ul> <li>alter the DNA ..."
<p>[[Epigenomics]]</p>
<p> </p>
<p>"Epi">>reversible</p>
<p> </p>
<p>definition : modifications on DNA /histones</p>
<ul>
<li>alter the DNA sequence</li>
</ul>
<p> </p>
<ul>
<li>Tumorigenesis : cancer --> expression / regulation change</li>
</ul>
<p> </p>
<p> </p>
<p>factor</p>
<ul>
<li>DNA methylation</li>
<li>
<ul>
<li>DNA methylase (DMNT)</li>
<li>effect</li>
<li>
<ul>
<li>imprinting : transfer certain environmental factor</li>
<li>X-chromosome inactivation</li>
<li>Heterochromatin maintenance</li>
<li>Developmental controls</li>
<li>Tissue specific expression controls</li>
</ul>
</li>
<li>How to sequence methylation?</li>
<li>
<ul>
<li>Biosulfite treatment of cytosine : cytosine --> uracil ( 5-methylcytosine residues is unaffected)</li>
</ul>
</li>
</ul>
</li>
</ul>
<p> </p>
<p>"Epi">>reversible</p>
<p> </p>
<p>definition : modifications on DNA /histones</p>
<ul>
<li>alter the DNA sequence</li>
</ul>
<p> </p>
<ul>
<li>Tumorigenesis : cancer --> expression / regulation change</li>
</ul>
<p> </p>
<p> </p>
<p>factor</p>
<ul>
<li>DNA methylation</li>
<li>
<ul>
<li>DNA methylase (DMNT)</li>
<li>effect</li>
<li>
<ul>
<li>imprinting : transfer certain environmental factor</li>
<li>X-chromosome inactivation</li>
<li>Heterochromatin maintenance</li>
<li>Developmental controls</li>
<li>Tissue specific expression controls</li>
</ul>
</li>
<li>How to sequence methylation?</li>
<li>
<ul>
<li>Biosulfite treatment of cytosine : cytosine --> uracil ( 5-methylcytosine residues is unaffected)</li>
</ul>
</li>
</ul>
</li>
</ul>
