Changes

From Biolecture.org

Lecture 5 - Proteomics & Epigenomics

109 bytes added, 00:17, 9 June 2017
no edit summary
Interaction proteomics =&gt; protein -protein association<br />
Protein family - protein mother, father</p>
 
<p>&nbsp;</p>
<p>The first person who identify the sequence of amino acid in protein. - Sanger(insulin)</p>
 
<p>&nbsp;</p>
<p>Pfam - the data base of protein family<br />
interproscan<br />
NCBI NR(non-redundant) db -&gt;largest data base -&gt; check the redundancy</p>
 
<p>&nbsp;</p>
<p>The level of any protein in the cell of&nbsp;<br />
3. the rate of degradation into half life of mRNA</p>
<p>&nbsp;</p> <p><strong>In my opinion, the number of possilble kinds of protein is 20^300(The number of type of amino acid is 20, and the average length of protein is 300aa -&gt;20*20*20*......*20 ) -&gt; protein space</strong></p> <p>&nbsp;</p>
<p>The number of protein types -&gt; about 100,000&nbsp;<br />
The number of type of protein structure -&gt; 4000~1000</p>
 
<p>&nbsp;</p>
<p>secondary structure - alpha helix/ beta sheet</p>
End point of polypeptide - C -terminus</p>
<p>domain - area/region of protein<br /p<p>determining protein structure<br />
1. X-ray crystallography<br />
2. NMR -&gt; sensor using magnetic radiation<br />

Navigation menu