Essay !10 - By using Drosophlia melanogaster protein sequence, Finding the human orthologue candidates and variants of w, sc, cdk1 Code : KSI0022
Genetics Homework # 3 – Genome browser
UNIST BIO - 20141110 Sangin Kim
White (w)
Drosophila melanogaster protein sequence of White (w)
>sp|P10090|WHITE_DROME Protein white OS=Drosophila melanogaster GN=w PE=2 SV=2
MGQEDQELLIRGGSKHPSAEHLNNGDSGAASQSCINQGFGQAKNYGTLLPPSPPEDSGSG
SGQLAENLTYAWHNMDIFGAVNQPGSGWRQLVNRTRGLFCNERHIPAPRKHLLKNVCGVA
YPGELLAVMGSSGAGKTTLLNALAFRSPQGIQVSPSGMRLLNGQPVDAKEMQARCAYVQQ
DDLFIGSLTAREHLIFQAMVRMPRHLTYRQRVARVDQVIQELSLSKCQHTIIGVPGRVKG
LSGGERKRLAFASEALTDPPLLICDEPTSGLDSFTAHSVVQVLKKLSQKGKTVILTIHQP
SSELFELFDKILLMAEGRVAFLGTPSEAVDFFSYVGAQCPTNYNPADFYVQVLAVVPGRE
IESRDRIAKICDNFAISKVARDMEQLLATKNLEKPLEQPENGYTYKATWFMQFRAVLWRS
WLSVLKEPLLVKVRLIQTTMVAILIGLIFLGQQLTQVGVMNINGAIFLFLTNMTFQNVFA
TINVFTSELPVFMREARSRLYRCDTYFLGKTIAELPLFLTVPLVFTAIAYPMIGLRAGVL
HFFNCLALVTLVANVSTSFGYLISCASSSTSMALSVGPPVIIPFLLFGGFFLNSGSVPVY
LKWLSYLSWFRYANEGLLINQWADVEPGEISCTSSNTTCPSSGKVILETLNFSAADLPLD
YVGLAILIVSFRVLAYLALRLRARRKE
Human orthologue candidates and comparing (w)
Many-to-many ortholog
Selected one of the human orthologue candidate and variants (w)
(1) Missense variants - 10718
(2) Synonymous variants - 6883
(3) Intronic variants - 248025
Scalloped (sc)
Drosophila melanogaster protein sequence of Scalloped (sc)
>sp|P30052|SCAL_DROME Protein scalloped OS=Drosophila melanogaster GN=sd PE=1 SV=1
MKNITSSSTCSTGLLQLQNNLSCSELEVAEKTEQQAVGPGTIPSPWTPVNAGPPGALGSA
DTNGSMVDSKNLDVGDMSDDEKDLSSADAEGVWSPDIEQSFQEALSIYPPCGRRKIILSD
EGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREIQAKIKVQFWQPGLQPST
SQDFYDYSIKPFPQPPYPAGKTSTAVSGDETGIPPSQLPWEGRAIATHKFRLLEFTAFME
IQRDEIYHRHLFVQLGGKPSFSDPLLETVDIRQIFDKFPEKSGGLKDLYEKGPQNAFYLV
KCWADLNTDLTTGSETGDFYGVTSQYESNENVVLVCSTIVCSFGKQVVEKVESEYSRLEN
NRYVYRIQRSPMCEYMINFIQKLKNLPERYMMNSVLENFTILQVMRARETQETLLCIAYV
FEVAAQNSGTTHHIYRLIKE
Human orthologue candidates and comparing (sc)
1-to-many ortholog
Selected one of the human orthologue candidate and variants (sc)
(1) Missense variants - 3527
(2) Synonymous variants - 2175
(3) Intronic variants - 145182
Cdk1
Drosophila melanogaster protein sequence of Cdk1
>sp|P23572|CDK1_DROME Cyclin-dependent kinase 1 OS=Drosophila melanogaster GN=Cdk1 PE=1 SV=1
MEDFEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIREISLLKELKH
ENIVCLEDVLMEENRIYLIFEFLSMDLKKYMDSLPVDKHMESELVRSYLYQITSAILFCH
RRRVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPR
YSCPVDIWSIGCIFAEMATRKPLFQGDSEIDQLFRMFRILKTPTEDIWPGVTSLPDYKNT
FPCWSTNQLTNQLKNLDANGIDLIQKMLIYDPVHRISAKDILEHPYFNGFQSGLVRN
Human orthologue candidates and comparing (Cdk1)
1 – to – 1 ortholog
Selected one of the human orthologue candidate and variants (Cdk1)
(1) Missense variants - 1354
(2) Synonymous variants - 958
(3) Intronic variants - 29424
2016.10.14.Fri
UNIST BIO Junior 20141110 Sangin Kim
