Essay !10 - By using Drosophlia melanogaster protein sequence, Finding the human orthologue candidates and variants of w, sc, cdk1 Code : KSI0022

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<Genomics Essay #10 – Genome browser>

 

UNIST BIO - 20141110 Sangin Kim

 

White (w)

Drosophila melanogaster protein sequence of White (w)

>sp|P10090|WHITE_DROME Protein white OS=Drosophila melanogaster GN=w PE=2 SV=2

MGQEDQELLIRGGSKHPSAEHLNNGDSGAASQSCINQGFGQAKNYGTLLPPSPPEDSGSG

SGQLAENLTYAWHNMDIFGAVNQPGSGWRQLVNRTRGLFCNERHIPAPRKHLLKNVCGVA

YPGELLAVMGSSGAGKTTLLNALAFRSPQGIQVSPSGMRLLNGQPVDAKEMQARCAYVQQ

DDLFIGSLTAREHLIFQAMVRMPRHLTYRQRVARVDQVIQELSLSKCQHTIIGVPGRVKG

LSGGERKRLAFASEALTDPPLLICDEPTSGLDSFTAHSVVQVLKKLSQKGKTVILTIHQP

SSELFELFDKILLMAEGRVAFLGTPSEAVDFFSYVGAQCPTNYNPADFYVQVLAVVPGRE

IESRDRIAKICDNFAISKVARDMEQLLATKNLEKPLEQPENGYTYKATWFMQFRAVLWRS

WLSVLKEPLLVKVRLIQTTMVAILIGLIFLGQQLTQVGVMNINGAIFLFLTNMTFQNVFA

TINVFTSELPVFMREARSRLYRCDTYFLGKTIAELPLFLTVPLVFTAIAYPMIGLRAGVL

HFFNCLALVTLVANVSTSFGYLISCASSSTSMALSVGPPVIIPFLLFGGFFLNSGSVPVY

LKWLSYLSWFRYANEGLLINQWADVEPGEISCTSSNTTCPSSGKVILETLNFSAADLPLD

YVGLAILIVSFRVLAYLALRLRARRKE

 

 

 

Human orthologue candidates and comparing (w)

 

 

Many-to-many ortholog

 

Selected one of the human orthologue candidate and variants (w)

 

 

(1) Missense variants - 10718

(2) Synonymous variants - 6883

(3) Intronic variants - 248025

 

 

Scalloped (sc)

Drosophila melanogaster protein sequence of Scalloped (sc)

>sp|P30052|SCAL_DROME Protein scalloped OS=Drosophila melanogaster GN=sd PE=1 SV=1

MKNITSSSTCSTGLLQLQNNLSCSELEVAEKTEQQAVGPGTIPSPWTPVNAGPPGALGSA

DTNGSMVDSKNLDVGDMSDDEKDLSSADAEGVWSPDIEQSFQEALSIYPPCGRRKIILSD

EGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREIQAKIKVQFWQPGLQPST

SQDFYDYSIKPFPQPPYPAGKTSTAVSGDETGIPPSQLPWEGRAIATHKFRLLEFTAFME

IQRDEIYHRHLFVQLGGKPSFSDPLLETVDIRQIFDKFPEKSGGLKDLYEKGPQNAFYLV

KCWADLNTDLTTGSETGDFYGVTSQYESNENVVLVCSTIVCSFGKQVVEKVESEYSRLEN

NRYVYRIQRSPMCEYMINFIQKLKNLPERYMMNSVLENFTILQVMRARETQETLLCIAYV

FEVAAQNSGTTHHIYRLIKE

 

 

 

Human orthologue candidates and comparing (sc)

1-to-many ortholog

 

 

Selected one of the human orthologue candidate and variants (sc)

(1) Missense variants - 3527

(2) Synonymous variants - 2175

(3) Intronic variants - 145182

 

 

Cdk1

Drosophila melanogaster protein sequence of Cdk1

>sp|P23572|CDK1_DROME Cyclin-dependent kinase 1 OS=Drosophila melanogaster GN=Cdk1 PE=1 SV=1

MEDFEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIREISLLKELKH

ENIVCLEDVLMEENRIYLIFEFLSMDLKKYMDSLPVDKHMESELVRSYLYQITSAILFCH

RRRVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPR

YSCPVDIWSIGCIFAEMATRKPLFQGDSEIDQLFRMFRILKTPTEDIWPGVTSLPDYKNT

FPCWSTNQLTNQLKNLDANGIDLIQKMLIYDPVHRISAKDILEHPYFNGFQSGLVRN

 

Human orthologue candidates and comparing (Cdk1)

 

 

1 – to – 1 ortholog

 

Selected one of the human orthologue candidate and variants (Cdk1)

(1) Missense variants - 1354

(2) Synonymous variants - 958

(3) Intronic variants - 29424

 

 

2016.10.14.Fri

UNIST BIO Junior 20141110 Sangin Kim

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