View source for Essay !10 - By using Drosophlia melanogaster protein sequence, Finding the human orthologue candidates and variants of w, sc, cdk1 Code : KSI0022

<p style="text-align:center"><span style="font-size:36px">&lt;Genomics&nbsp;Essay&nbsp;#10 &ndash; Genome browser&gt;</span></p>

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<p style="text-align:right"><strong>UNIST BIO - 20141110 Sangin Kim</strong></p>

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<p style="text-align:center"><span style="color:#008000"><strong><span style="font-size:28px">White (w)</span></strong></span></p>

<p><strong>Drosophila melanogaster protein sequence of White (w)</strong></p>

<p>&gt;sp|P10090|WHITE_DROME Protein white OS=Drosophila melanogaster GN=w PE=2 SV=2</p>

<p>MGQEDQELLIRGGSKHPSAEHLNNGDSGAASQSCINQGFGQAKNYGTLLPPSPPEDSGSG</p>

<p>SGQLAENLTYAWHNMDIFGAVNQPGSGWRQLVNRTRGLFCNERHIPAPRKHLLKNVCGVA</p>

<p>YPGELLAVMGSSGAGKTTLLNALAFRSPQGIQVSPSGMRLLNGQPVDAKEMQARCAYVQQ</p>

<p>DDLFIGSLTAREHLIFQAMVRMPRHLTYRQRVARVDQVIQELSLSKCQHTIIGVPGRVKG</p>

<p>LSGGERKRLAFASEALTDPPLLICDEPTSGLDSFTAHSVVQVLKKLSQKGKTVILTIHQP</p>

<p>SSELFELFDKILLMAEGRVAFLGTPSEAVDFFSYVGAQCPTNYNPADFYVQVLAVVPGRE</p>

<p>IESRDRIAKICDNFAISKVARDMEQLLATKNLEKPLEQPENGYTYKATWFMQFRAVLWRS</p>

<p>WLSVLKEPLLVKVRLIQTTMVAILIGLIFLGQQLTQVGVMNINGAIFLFLTNMTFQNVFA</p>

<p>TINVFTSELPVFMREARSRLYRCDTYFLGKTIAELPLFLTVPLVFTAIAYPMIGLRAGVL</p>

<p>HFFNCLALVTLVANVSTSFGYLISCASSSTSMALSVGPPVIIPFLLFGGFFLNSGSVPVY</p>

<p>LKWLSYLSWFRYANEGLLINQWADVEPGEISCTSSNTTCPSSGKVILETLNFSAADLPLD</p>

<p>YVGLAILIVSFRVLAYLALRLRARRKE</p>

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<p><img alt="" src="/ckfinder/userfiles/images/noname01.PNG" style="height:212px; width:1072px" /></p>

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<p><strong>Human orthologue candidates and comparing (w)</strong></p>

<p><img alt="" src="/ckfinder/userfiles/images/noname02.PNG" style="height:463px; width:1110px" /></p>

<p><img alt="" src="/ckfinder/userfiles/images/noname03.PNG" style="height:38px; width:1119px" /></p>

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<p><img alt="" src="/ckfinder/userfiles/images/noname04.PNG" style="height:642px; width:1138px" /></p>

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<p>Many-to-many ortholog</p>

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<p><strong>Selected one of the human orthologue candidate and variants (w)</strong></p>

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<p><img alt="" src="/ckfinder/userfiles/images/noname05.PNG" style="height:494px; width:684px" /></p>

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<p>(1) Missense variants - 10718</p>

<p>(2) Synonymous variants - 6883</p>

<p>(3) Intronic variants - 248025</p>

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<p style="text-align:center"><span style="color:#008000"><strong><span style="font-size:28px">Scalloped (sc)</span></strong></span></p>

<p><strong>Drosophila melanogaster protein sequence of Scalloped (sc)</strong></p>

<p>&gt;sp|P30052|SCAL_DROME Protein scalloped OS=Drosophila melanogaster GN=sd PE=1 SV=1</p>

<p>MKNITSSSTCSTGLLQLQNNLSCSELEVAEKTEQQAVGPGTIPSPWTPVNAGPPGALGSA</p>

<p>DTNGSMVDSKNLDVGDMSDDEKDLSSADAEGVWSPDIEQSFQEALSIYPPCGRRKIILSD</p>

<p>EGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREIQAKIKVQFWQPGLQPST</p>

<p>SQDFYDYSIKPFPQPPYPAGKTSTAVSGDETGIPPSQLPWEGRAIATHKFRLLEFTAFME</p>

<p>IQRDEIYHRHLFVQLGGKPSFSDPLLETVDIRQIFDKFPEKSGGLKDLYEKGPQNAFYLV</p>

<p>KCWADLNTDLTTGSETGDFYGVTSQYESNENVVLVCSTIVCSFGKQVVEKVESEYSRLEN</p>

<p>NRYVYRIQRSPMCEYMINFIQKLKNLPERYMMNSVLENFTILQVMRARETQETLLCIAYV</p>

<p>FEVAAQNSGTTHHIYRLIKE</p>

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<p><img alt="" src="/ckfinder/userfiles/images/noname06.PNG" style="height:164px; width:1003px" /></p>

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<p><img alt="" src="/ckfinder/userfiles/images/noname07.PNG" style="height:368px; width:1136px" /></p>

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<p><strong>Human orthologue candidates and comparing (sc)</strong></p>

<p><img alt="" src="/ckfinder/userfiles/images/noname08.PNG" style="height:33px; width:1119px" /></p>

<p><img alt="" src="/ckfinder/userfiles/images/noname09.PNG" style="height:71px; width:1121px" /></p>

<p>1-to-many ortholog</p>

<p>&nbsp;</p>

<p>&nbsp;</p>

<p><strong>Selected one of the human orthologue candidate and variants (sc)</strong></p>

<p><img alt="" src="/ckfinder/userfiles/images/noname10.PNG" style="height:490px; width:685px" /></p>

<p>(1) Missense variants - 3527</p>

<p>(2) Synonymous variants - 2175</p>

<p>(3) Intronic variants - 145182</p>

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<p style="text-align:center"><span style="color:#008000"><span style="font-size:28px"><strong>Cdk1</strong></span></span></p>

<p><strong>Drosophila melanogaster protein sequence of Cdk1</strong></p>

<p>&gt;sp|P23572|CDK1_DROME Cyclin-dependent kinase 1 OS=Drosophila melanogaster GN=Cdk1 PE=1 SV=1</p>

<p>MEDFEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIREISLLKELKH</p>

<p>ENIVCLEDVLMEENRIYLIFEFLSMDLKKYMDSLPVDKHMESELVRSYLYQITSAILFCH</p>

<p>RRRVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPR</p>

<p>YSCPVDIWSIGCIFAEMATRKPLFQGDSEIDQLFRMFRILKTPTEDIWPGVTSLPDYKNT</p>

<p>FPCWSTNQLTNQLKNLDANGIDLIQKMLIYDPVHRISAKDILEHPYFNGFQSGLVRN</p>

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<p><img alt="" src="/ckfinder/userfiles/images/noname11.PNG" style="height:163px; width:989px" /></p>

<p><strong>Human orthologue candidates and comparing (Cdk1)</strong></p>

<p><img alt="" src="/ckfinder/userfiles/images/noname12.PNG" style="height:374px; width:1128px" /></p>

<p>&nbsp;</p>

<p><img alt="" src="/ckfinder/userfiles/images/noname13.PNG" style="height:33px; width:1119px" /></p>

<p><img alt="" src="/ckfinder/userfiles/images/noname14.PNG" style="height:74px; width:1117px" /></p>

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<p>1 &ndash; to &ndash; 1 ortholog</p>

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<p><strong>Selected one of the human orthologue candidate and variants (Cdk1)</strong></p>

<p><img alt="" src="/ckfinder/userfiles/images/noname15.PNG" style="height:486px; width:680px" /></p>

<p>(1) Missense variants - 1354</p>

<p>(2) Synonymous variants - 958</p>

<p>(3) Intronic variants - 29424</p>

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<p style="text-align:right">2016.10.14.Fri</p>

<p style="text-align:right">UNIST BIO Junior 20141110 Sangin Kim</p>