Genomics for JS

Genomics database by Mike

SNPedia : (www.snpedia.com)

For examples..

• http://snpedia.com/index.php/Rs279858
• http://snpedia.com/index.php/Rs4818

Promethease : (www,promethease.com)

For example..

• http://files.snpedia.com/reports/promethease_data/genome_Lilly_Mendel_v4_ui2.html

 

Research approches by presentation

• hypothesis-driven : candidate gene studies
• data-driven (hypothesis-generating) : familiy linakge studies, genome wide association studies
• which one is better? nothing is better.

-> family linkage study + genome wide association study = candidate gene association study (hypothesis -> target gene search, specific gene research possibly, but unpredictable gene reasearch impossibly)

-> limitation : it is remained to examine functional implications and identify the casual gene, gene doesn't tell about everything.

 

Genomics in the lecture

• Geno + Envriro = Pheno
• Solution : exact data, principles, laws, algorithms, etc..
• Typing : Sequencing -> Imaging
• For example : High altitude adaptation, baleen whale -> hypothesis-driven

•          Expression -> gene product

           RFAM : database

           RNA species

           How does RNA regulate exercise? What does RNA make regulation work?

  Horse genome (6) alternative splicing

  RNA -> short preriod time (30 min)