2017.06.02 YS
From Biolecture.org
- Marker
- SNP(Single Nucleotide Polymorphism)
⇒ is a variation in a single nucleotide that occurs at a specific position in the genome, where each variation is present to some appreciable degree within a population.[1]
⇒ 한개의 염기서열이 바뀐 부분을 말한다
- Functional genomics
- Transcription / Translation
⇒ Transcription : reflection (mirror) / DNA → RNA
⇒ Translation : make different / 3 base pair(codon) → 1 Amino acid
- DNA / RNA
⇒ 가장 큰 차이점은 oxygen
⇒ DNA는 oxygen이 없기때문에 stable / RNA 는 oxygen이 존재함
- Which protein make more in cell?
protein A : stable mRNA, transcribe 5
protein B : unstable mRNA, transcribe 100
⇒ answer is A
stable 한 mRNA가 cell 내에 더 오래 머물기 때문에 더 많은 protein을 만든다.
blue is A , red is B
- Hidden markov model (HMM)
- RNA는 environment change에 따라 차이가 있으니까 연구에 활용 가능할 듯.
[1] https://en.wikipedia.org/wiki/Single-nucleotide_polymorphism
