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4. Transcriptomics Class (0603)

1 byte added, 21:49, 13 June 2016
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<p style="margin-left: 40px">&nbsp;RNA is classified into two categories, coding RNA and non coding RNA. Messenger RNA is included in the coding RNA. It means that they encode amino acid sequences, so they act as template for protein synthesis. It consists of 5&rsquo; cap, 5&rsquo; UTR, coding sequence, 3&rsquo; UTR, Poly-A tail.</p>
<p><strong>&nbsp;&nbsp; What is a UTR?</strong></p>
<p style="margin-left: 40px">&nbsp;It is untranslated region in the mRNA. There are two UTR, one exists before the start codon, 5&rsquo; UTR, and the other exists after the start codon, 3&rsquo; UTR. They have roles in the mRNA stability, mRNA localization, and translational efficiency. mRNA stability is controlled by RNA degrading enzyme which is controlled by UTR. UTR have some information about localization of mRNA. Also, UTR regulate translation efficiency by affecting the ribosome binding to the mRNA.</p>
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