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Toxicogenomics

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<p>The nature and complexity of the data (in volume and variability) demands highly developed processes for of automated handling and storage. The analysis usually involves a wide array of bioinformatics and statistics.<sup class="reference" id="cite_ref-3"><span>[</span>4<span>]</span></sup>, regularly involving classification approaches<sup class="reference" id="cite_ref-4"><span>[</span>5<span>]</span></sup>.</p>
<p>In pharmaceutical Drug discovery and development toxicogenomics is used to study adverse, i.e. toxic, effects, of pharmaceutical drugs in defined model systems in order to draw conclusions on the toxic risk to patients or the environment. Both the EPA and the U.S. Food and Drug Administration currently preclude basing regulatory decision making on genomics data alone. However, they do encourage the voluntary submission of well-documented, quality genomics data. Both agencies are considering the use of submitted data on a case-by-case basis for assessment purposes (e.g., to help elucidate mechanism of action or contribute to a weight-of-evidence approach) or for populating relevant comparative databases by encouraging parallel submissions of genomics data and traditional toxicologic test results.<sup class="reference" id="cite_ref-5"><span>[</span>6<span>]</span></sup></p>
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<h2><span class="mw-headline">Public Toxicogenomics Projects</span></h2>
<h2><span class="mw-headline">External links</span></h2>
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<li><a class="external text" title="http://ctd.mdibl.org/" rel="nofollow" href="http://ctd.mdibl.org/" rel="nofollow">Comparative Toxicogenomics Database</a> - a public database that integrates toxicogenomic data for chemicals, genes, and diseases from the scientific literature. </li> <li><a class="external text" title="http://www.ohsu.edu/croet/research/centers/toxicogenomics/whatis.html" rel="nofollow" href="http://www.ohsu.edu/croet/research/centers/toxicogenomics/whatis.html" rel="nofollow">Center for Research on Occupational and Environmental Toxicology</a> definition by the CROET Research Centers: (Neuro)toxicogenomics and Child Health Research Center. </li> <li><a class="external text" title="http://www.innomed-predtox.com/" rel="nofollow" href="http://www.innomed-predtox.com/" rel="nofollow">InnoMed PredTox</a> - official project website </li> <li><a class="external text" title="http://www.epa.gov/ncct/toxcast/" rel="nofollow" href="http://www.epa.gov/ncct/toxcast/" rel="nofollow">ToxCast</a> - official project website </li>
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