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Created page with "'''Research interst''' of Hyeongkyu Kim (MS-Ph.D. candidate in Professor Tae-eun Park laboratory)<br/> <br/> ''''Choroid plexus on chip''''<br/> Choroid plexus is a extre..."
'''Research interst''' of Hyeongkyu Kim (MS-Ph.D. candidate in Professor Tae-eun Park laboratory)<br/> <br/> ''''Choroid plexus on chip''''<br/> Choroid plexus is a extremely understudied tissue. To advance our understanding, in vitro modeling of choroid plexus is needed.<br/> Considering the native structure of choroid plexus, it is better to be recapitulated in microfluidic system rather than organoid.<br/> <br/> '''[single cell RNA sequencing]'''<br/> Among choroid plexus epithelial cells, there are undefined subtypes. To identify these unknown subtypes, lab-grown choroid plexus tissue will be analyzed by scRNAseq.<br/> There many problems to use human brain tissue<br/> <br/> '''[Proteomics]'''<br/> Choroid plexus produce cerebrospinal fluid. It contains numerous neurotrophic factor that can rejuvenate adult brain.<br/> To validate 'choroid plexus on chip' that it can produce authentic CSF, the chip-derived CSF will be analyzed by proteomics and be compared with patient-derived CSF.<br/> <br/> '''Reference'''<br/> Pellegrini. ''et al.,'' "Human CNS barrier-forming organoids with cerebrospinal fluid production.", ''Science,'' (2020)