Changes

<p class="MsoNormal" style="margin: 0cm 0cm 8pt"><span style="font-size: small"><span lang="EN-US"><font face="맑은 고딕">Epigenetics</font></span></span><span lang="EN-US"><font size="2"><font face="맑은 고딕">Epigenetics<o:p></o:p></font></font></span></p><p class="MsoListParagraph" style="margin: 0cm 0cm 8pt 38pt; text-indent: -18pt; mso-para-margin-left: 0gd; mso-list: l0 level1 lfo1"><span langstyle="ENfont-size: small"><span lang="EN-US" style="mso-fareast-font-family: &quot;맑은 고딕&quot;; mso-fareast-theme-font: minor-latin; mso-bidi-font-family: &quot;맑은 고딕&quot;; mso-bidi-theme-font: minor-latin"><span style="mso-list: Ignore"><font size="2" face="맑은 고딕">1.</font><span style="font: 7pt &quot;Times New Roman&quot;">&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span><span lang="EN-US"><font size="2"><font face="맑은 고딕">Definition</font></fontspan></span></p><p class="MsoListParagraph" style="margin: 0cm 0cm 8pt 38pt; text-indent: -18pt; mso-para-margin-left: 0gd; mso-list: l0 level1 lfo1"><span langstyle="ENfont-USsize: small"><font sizespan lang="2EN-US">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </font></span><span lang="EN-US"><font sizeface="2"><font face="맑은 맑은 고딕">It is the study of epigenetic modifications; RNA interference, DNA methylation, Histone modification (acetylation, phosphorylation) without modification of DNA genetic codes. </font></span></span><span lang="EN-US"><font size="2"><font face="맑은 고딕"><o:p></o:p></font></font></span></p><p class="MsoListParagraph" style="margin: 0cm 0cm 8pt 38pt; text-indent: -18pt; mso-para-margin-left: 0gd; mso-list: l0 level1 lfo1"><span style="font-size: small"><span lang="EN-US" style="mso-fareast-font-family: &quot;맑은 고딕&quot;; mso-fareast-theme-font: minor-latin; mso-bidi-font-family: &quot;맑은 고딕&quot;; mso-bidi-theme-font: minor-latin"><span style="mso-list: Ignore"><font size="2" face="맑은 고딕">2.</font><span style="font: 7pt &quot;Times New Roman&quot;">&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span><span lang="EN-US"><font size="2"><font face="맑은 고딕">Study<o:p></o:p></font></fontspan></span></p><p classspan lang="MsoListParagraph" style="margin: 0cm 0cm 8pt 38pt; text-indent: -18pt; mso-para-margin-left: 0gd; mso-list: l0 level1 lfo1"><span lang="EN-EN-US"><font size="2"><font face="맑은 고딕">&nbsp<o:p></o:p></font></font></span></p><p class="MsoListParagraph" style="margin: 0cm 0cm 8pt 38pt;&nbsptext-indent: -18pt;&nbspmso-para-margin-left: 0gd;&nbsp; According to pass the time which means organisms getting older, the number of mso-list: l0 level1 lfo1"><span style="font-size: small"><span lang="EN-US"><font face="맑은 고딕">&nbsp;&nbsp;&nbsp;&nbsp; According to pass the time which means organisms getting older, the number of DNA methylation on cysteine is larger. That means life is set of signal recording environmental information which gene codes are necessary for the kinds of adaption. Gene expression is not only differentiated by gene&rsquo;s own information but also regulated by modification on histonee and addition of many functional groups. Comparing number of genes S.pombe and S.cereveisiae that are the single eukaryotic cells and human shows us human has less number of them. However human is more complicate complex which means even though we have less number of single cell organisms, humankinds have more intricate switches to express various gene expression in a same DNA. This switches are composed by DNA, RNA, histone modification. </font></span></span><span lang="EN-US"><font size="2"><font face="맑은 고딕"><o:p></o:p></font></font></span></p><p class="MsoListParagraph" style="margin: 0cm 0cm 8pt 38pt; mso-para-margin-left: 0gd"><span langstyle="ENfont-USsize: small"><font sizespan lang="2EN-US"><font face="맑은 고딕">In case of Egg, for baby, its cytoplasm is the tank of histone, RNA, regulating proteins. Therefore, epigenetic heredity is possible continuously passing the time and descendants. </font></span></span><span lang="EN-US"><font size="2"><font face="맑은 고딕"><o:p></o:p></font></font></span></p><p class="MsoListParagraph" style="margin: 0cm 0cm 8pt 38pt; text-indent: -18pt; mso-para-margin-left: 0gd; mso-list: l0 level1 lfo1"><span langstyle="font-size: small"><span lang="EN-US" style="mso-fareast-font-family: &quot;맑은 고딕&quot;; mso-fareast-theme-font: minor-latin; mso-bidi-font-family: &quot;맑은 고딕&quot;; mso-bidi-theme-font: minor-latin"><span style="mso-list: Ignore"><font size="2" face="맑은 고딕">3.</font><span style="font: 7pt &quot;Times New Roman&quot;">&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span><span lang="EN-US"><font face="맑은 고딕">Methylation</font></span></span><span lang="EN-US"><font size="2"><font face="맑은 고딕">Methylation<o:p></o:p></font></font></span></p><p class="MsoListParagraph" style="margin: 0cm 0cm 8pt 38pt; text-indent: -18pt; mso-para-margin-left: 0gd; mso-list: l0 level1 lfo1"><span langstyle="ENfont-USsize: small"><font sizespan lang="2EN-US"><font face="맑은 고딕">&nbsp;&nbsp;&nbsp;&nbsp; Methylation on cytosine is well known in DNA. How to figure out whether it is methylated cytosine or thymine, because they have similar structures, is make complementary DNA strand. It has G which is complementary to methylated cytosine and A which is complementary to thymine. <o:p></o:p></font></fontspan></span></pspan lang="EN-US"><p classfont size="MsoListParagraph2" style=><font face="맑은 고딕"><o:p></o:p></font></font></span></p><p class="MsoListParagraph" style="margin: 0cm 0cm 8pt 38pt; text-indent: -18pt; mso-para-margin-left: 0gd; mso-list: l0 level1 lfo1"><span langstyle="font-size: small"><span lang="EN-US" style="mso-fareast-font-family: &quot;맑은 고딕&quot;; mso-fareast-theme-font: minor-latin; mso-bidi-font-family: &quot;맑은 고딕&quot;; mso-bidi-theme-font: minor-latin"><span style="mso-list: Ignore"><font size="2" face="맑은 고딕">4.</font><span style="font: 7pt &quot;Times New Roman&quot;">&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span><span lang="EN-US"><font size="2"><font face="맑은 고딕">Allele</font></fontspan></span></p><p class="MsoListParagraph" style="margin: 0cm 0cm 8pt 38pt; text-indent: -18pt; mso-para-margin-left: 0gd; mso-list: l0 level1 lfo1"><span langstyle="ENfont-USsize: small"><font sizespan lang="2EN-US">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </font></span><font face="맑은 고딕"><span lang="EN" style="mso-ansi-language: EN"><font size="2">one of one of a number of alternative forms of the same </span></font><a title/span><font face="Gene맑은 고딕" href><span lang="http://en.wikipedia.org/wiki/GeneEN"><span style="textmso-decoration: none; color: windowtext; textansi-underlinelanguage: noneEN"><font sizespan style="2">gene</font></span></a><font -size="2: small"> or same </font><a title="Locus (genetics)Gene" href="http://en.wikipedia.org/wiki/Locus_(genetics)Gene"><span style="text-decoration: none; color: windowtext; text-underline: none">gene<font size="2"/span>genetic locus</fonta>or same </span></a></span><span langstyle="EN"><font -size="2: small"> </font></span><span lang="EN" style="mso-ansi-language: EN"><font size="2">different alleles can result in different observable </font><a a title="Phenotypic traitLocus (genetics)" href="http://en.wikipedia.org/wiki/Phenotypic_traitLocus_(genetics)"><span style="text-decoration: none; color: windowtext; text-underline: none">genetic locus<font size="2"/span>phenotypic traits</fonta></span></a><font sizespan lang="2EN">, such as different </fontspan><a titlespan lang="PigmentationEN" hrefstyle="httpmso-ansi-language://en.wikipedia.org/wiki/PigmentationEN">different alleles can result in different observable </span style></span><span lang="EN" style="textmso-decoration: none; color: windowtext; textansi-underlinelanguage: noneEN"><span style="font -size="2: small">pigmentation</font></span></a><font sizetitle="2Phenotypic trait" href=">http://en. However, most genetic variations result in little or no observable variationwikipedia. <org/font><wiki/span></fontPhenotypic_trait"><span lang="EN" style="msotext-ansidecoration: none; color: windowtext; text-languageunderline: ENnone">phenotypic traits<a href="http:/span></en.wikipedia.orga>, such as different </wikispan></Allele"span></font color><span style="#0000ff" font-size="2: small" ><font face="맑은 고딕"><span lang="EN" style="mso-ansi-language: EN"><a title="Pigmentation" href="http://en.wikipedia.org/wiki/AllelePigmentation"><span style="text-decoration: none; color: windowtext; text-underline: none">pigmentation</fontspan></a>. However, most genetic variations result in little or no observable variation. <font size="2"/span></font face="맑은 고딕">)<o:p></o:p></font></fontspan></span></p><p classlang="MsoListParagraphEN" style="marginmso-ansi-language: 0cm 0cm 8pt 38pt; text-indent: -18pt; mso-para-margin-left: 0gd; mso-list: l0 level1 lfo1EN"><span langa href="ENhttp://en.wikipedia.org/wiki/Allele" ><span style="mso-fareastfont-size: small"><font-family: &quot;color="#0000ff" face="맑은 고딕&quot;; mso-fareast-theme-font">http: minor-latin; mso-bidi-//en.wikipedia.org/wiki/Allele</font></span></a><span style="font-familysize: &quot;small"><font face="맑은 고딕&quot;; mso-bidi-theme-font: minor-latin; mso-ansi-language: EN"">)</font></span style="mso-list: Ignore"><font size="2" ><font face="맑은 고딕">5.<o:p></o:p></font><span style="/font: 7pt &quot;Times New Roman&quot;">&nbsp;&nbsp;&nbsp;&nbsp; </span></span></spanp><span langp class="ENMsoListParagraph" style="mso-ansi-languagemargin: EN0cm 0cm 8pt 38pt; text-indent: -18pt; mso-para-margin-left: 0gd; mso-list: l0 level1 lfo1"><span style="font -size="2: small"><font facespan lang="맑은 고딕EN" style=">Darwinian Evolution <omso-fareast-font-family:p></o&quot;맑은 고딕&quot;; mso-fareast-theme-font:p></minor-latin; mso-bidi-font></-family: &quot;맑은 고딕&quot;; mso-bidi-theme-font: minor-latin; mso-ansi-language: EN"></span></p><p class="MsoListParagraph" style="marginmso-list: 0cm 0cm 8pt 38pt; text-indent: -18pt; mso-para-margin-left: 0gd; mso-list: l0 level1 lfo1"Ignore"><span langfont face="EN맑은 고딕" >5.</font><span style="mso-ansi-languagefont: EN"><font size="2" face="맑은 고딕7pt &quot;Times New Roman&quot;">&nbsp;&nbsp;&nbsp;&nbsp; Is based on natural selection that is gradual process by which heritable </fontspan><a title/span></span><span lang="Trait (biology)EN" hrefstyle="httpmso-ansi-language://en.wikipedia.org/wiki/Trait_(biology)EN"><span stylefont face="text-decoration: none; color: windowtext; text맑은 고딕">Darwinian Evolution </font></span></span><span lang="EN" style="mso-ansi-underlinelanguage: noneEN"><font size="2" ><font face="맑은 고딕">biological traits</fonto:p></spano:p></afont></font size="2" face="맑은 고딕"> become either more or less common in a </fontspan></p><a titlep class="PopulationMsoListParagraph" hrefstyle="httpmargin://en.wikipedia.org/wiki/Population"><span style="0cm 0cm 8pt 38pt; text-decorationindent: none-18pt; colormso-para-margin-left: windowtext0gd; textmso-underlinelist: nonel0 level1 lfo1"><span style="font -size=: small"2><span lang="EN" style="mso-ansi-language: EN" ><font face="맑은 고딕">population&nbsp;&nbsp;&nbsp;&nbsp; Is based on natural selection that is gradual process by which heritable </font></span></aspan><font sizespan lang="2EN" facestyle="맑은 고딕mso-ansi-language: EN"> as a function of the effect of inherited traits on the differential </span style="font-size: small"><a title="Reproductive successTrait (biology)" href="http://en.wikipedia.org/wiki/Reproductive_success"Trait_(biology)"><span style="text-decoration: none; color: windowtext; text-underline: none"><font size="2" face="맑은 고딕">reproductive successbiological traits</font></span></a><font size="2" face="맑은 고딕"> of organisms interacting with their environment. It is become either more or less common in a key mechanism of </font><a title/span><span style="Evolution" font-size: small"><a title="Population" href="http://en.wikipedia.org/wiki/EvolutionPopulation"><span style="text-decoration: none; color: windowtext; text-underline: none"><font size="2" face="맑은 고딕">evolutionpopulation</font></span></a><font size="2" face="맑은 고딕">. This occurs partly because random mutations arise in as a function of the effect of inherited traits on the differential </font><a /span><span style="font-size: small"><a title="GenomeReproductive success" href="http://en.wikipedia.org/wiki/GenomeReproductive_success"><span style="text-decoration: none; color: windowtext; text-underline: none"><font size="2" face="맑은 고딕">genomereproductive success</font></span></a><font size="2"><font face="맑은 고딕"> of an individual organism, and these mutations can be passed to offspring. Throughout the individuals&rsquo; lives, their genomes interact with their environments to cause variations in traits. (The environment organisms interacting with their environment. It is a key mechanism of a genome includes the molecular biology in the cell, other cells, other individuals, populations, species, as well as the abiotic environment</font></span><span style="font-size: small"><a title="Evolution" href="http://en.) Individuals with certain variants of the trait may survive and reproduce more than individuals with other, less successful, variantswikipedia. Therefore the population evolves. <org/font><wiki/font></spanEvolution"><span lang="EN" style="msotext-ansidecoration: none; color: windowtext; text-languageunderline: ENnone"><font sizeface="2맑은 고딕">evolution</font></span></a><font face="맑은 고딕">(. This occurs partly because random mutations arise in the <a href="http://en.wikipedia.org/wiki/Natural_selection"font>http://en.wikipedia.org/wiki/Natural_selection</a>)<o:pspan></o:pspan></span style="font-size: small"></font></span></p><p classspan lang="MsoListParagraphEN" style="margin: 0cm 0cm 8pt 38pt; text-indent: -18pt; mso-paraansi-margin-leftlanguage: 0gd; mso-list: l0 level1 lfo1EN"><span langa title="Genome" href="ENhttp://en.wikipedia.org/wiki/Genome" ><span style="msotext-fareast-font-familydecoration: &quotnone;맑은 고딕&quotcolor: windowtext;; mso-fareast-themetext-underline: none"><font: minor-latin; mso-bidi-font-family: &quot;face="맑은 고딕&quot;; mso-bidi-theme-">genome</font: minor-latin; mso-ansi-language: EN">></span><span style="mso-list: Ignore"/a><font size="2" face="맑은 고딕">6of an individual organism, and these mutations can be passed to offspring.</font><span style="font: 7pt Throughout the individuals&quotrsquo;Times New Roman&quot;">&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span><font size="2"><font face="맑은 고딕"lives, their genomes interact with their environments to cause variations in traits. (The environment of a genome includes the molecular biology in the cell, other cells, other individuals, populations, species, as well as the abiotic environment.) Individuals with certain variants of the trait may survive and reproduce more than individuals with other, less successful, variants. Therefore the population evolves. </font></span><span lang="EN" style="mso-ansi-language: EN; mso-bidi-"><font-weight: boldface="맑은 고딕">Lamarckian inheritance </span>(</font></fontspan></pspan><p classspan lang="MsoListParagraphEN" style="margin: 0cm 0cm 8pt 38pt; text-indent: -18pt; mso-paraansi-margin-leftlanguage: 0gd; mso-list: l0 level1 lfo1EN"><font size="2"><font face="맑은 고딕">&nbsp;&nbsp;&nbsp;&nbsp; <a href="http://en.wikipedia.org/font><wiki/fontNatural_selection"><span langstyle="EN" style="msofont-ansi-languagesize: EN"><font size="2" face="맑은 고딕small">the </font><a title="Idea" href="http://en.wikipedia.org/wiki/Idea"Natural_selection</span><span style/a><span style="textfont-decorationsize: none; colorsmall">)</span><o: windowtext; text-underlinep></o: none"p></font size="2" face="맑은 고딕">idea</font></span></ap><font sizep class="2MsoListParagraph" facestyle="맑은 고딕margin: 0cm 0cm 8pt 38pt; text-indent: -18pt; mso-para-margin-left: 0gd; mso-list: l0 level1 lfo1"> that an </font><a titlespan style="Organism" href="httpfont-size://en.wikipedia.org/wiki/Organismsmall"><span lang="EN" style="textmso-fareast-font-decorationfamily: none&quot; color: windowtext; text맑은 고딕&quot;; mso-fareast-theme-underlinefont: none"><minor-latin; mso-bidi-font size="2" face="-family: &quot;맑은 고딕">organism</&quot;; mso-bidi-theme-font: minor-latin; mso-ansi-language: EN"></span></astyle="mso-list: Ignore"><font size="2" face="맑은 고딕"> can pass on characteristics that it acquired during its lifetime to its </font><a title="Offspring" href="http://en.wikipedia.org/wiki/Offspring">6.</font><span style="text-decorationfont: none7pt &quot; color: windowtextTimes New Roman&quot; text-underline: none"><font size="2" face="맑은 고딕">offspring&nbsp;&nbsp;&nbsp;&nbsp; </fontspan></span></aspan><font size="2" face="맑은 고딕"> (also known as </font><a title<span lang="Inheritance of acquired characteristics" href="http://en.wikipedia.org/wiki/Inheritance_of_acquired_characteristicsEN"><span style="textmso-ansi-decorationlanguage: noneEN; color: windowtext; textmso-bidi-font-underlineweight: nonebold">Lamarckian inheritance <font size="2" face="맑은 고딕"/span>heritability of acquired characteristics</font></span></ap><font sizep class="2MsoListParagraph" facestyle="맑은 고딕"margin: 0cm 0cm 8pt 38pt; text-indent: -18pt; mso-para-margin-left: 0gd; mso-list: l0 level1 lfo1"> or </span style="font-size: small"><a titlefont face="Soft inheritance맑은 고딕" href="http:>&nbsp;&nbsp;&nbsp;&nbsp; <//en.wikipedia.org/wiki/Soft_inheritance"font><span lang="EN" style="textmso-decoration: none; color: windowtext; textansi-underlinelanguage: noneEN"><font size="2" face="맑은 고딕">soft inheritancethe </font></span></aspan><font sizespan lang="2EN" facestyle="맑은 고딕mso-ansi-language: EN">). Forms of 'soft' or </span style="font-size: small"><a title="EpigeneticsIdea" href="http://en.wikipedia.org/wiki/EpigeneticsIdea"><span style="text-decoration: none; color: windowtext; text-underline: none"><font size="2" face="맑은 고딕">epigenetic inheritanceidea</font></span></a><font size="2" face="맑은 고딕"> within organisms have been suggested as neo-Lamarckian in nature by such scientists as that an </font></span><span style="font-size: small"><a title="Eva JablonkaOrganism" href="http://en.wikipedia.org/wiki/Eva_JablonkaOrganism"><span style="text-decoration: none; color: windowtext; text-underline: none"><font size="2" face="맑은 고딕">Eva Jablonkaorganism</font></span></a><font size="2" face="맑은 고딕"> and can pass on characteristics that it acquired during its lifetime to its </font></span><span style="font-size: small"><a title="Marion J. Lamb"Offspring" href="http://en.wikipedia.org/wiki/Marion_J._LambOffspring"><span style="text-decoration: none; color: windowtext; text-underline: none"><font size="2" face="맑은 고딕">Marion J. Lamboffspring</font></span></a><font size="2" face="맑은 고딕">. In addition to 'hard' or genetic inheritance, involving the duplication of genetic material and its segregation during (also known as </font></span><span style="font-size: small"><a title="MeiosisInheritance of acquired characteristics" href="http://en.wikipedia.org/wiki/MeiosisInheritance_of_acquired_characteristics"><span style="text-decoration: none; color: windowtext; text-underline: none"><font size="2" face="맑은 고딕">meiosisheritability of acquired characteristics</font></span></a><font size="2" face="맑은 고딕">, there are other hereditary elements that pass into the germ cells also. These include things like or </font></span></span style="font-size: small"><a title="DNA methylationSoft inheritance" href="http://en.wikipedia.org/wiki/DNA_methylationSoft_inheritance"><span style="text-decoration: none; color: windowtext; text-underline: none"><font size="2" face="맑은 고딕">methylationsoft inheritance</font></span></a><font size="2" face="맑은 고딕"> patterns in DNA and ). Forms of 'soft' or </font></span><span style="font-size: small"><a title="ChromatinEpigenetics" href="http://en.wikipedia.org/wiki/ChromatinEpigenetics"><span style="text-decoration: none; color: windowtext; text-underline: none"><font size="2" face="맑은 고딕">chromatinepigenetic inheritance</font></span></a><font size="2"><font face="맑은 고딕"> marks, both of which regulate the activity of genes </font>within organisms have been suggested as neo-Lamarckian in nature by such scientists as </font></span><span lang="EN" style="msofont-ansi-languagesize: ENsmall"><a title="Eva Jablonka" href="http://en.wikipedia.org/wiki/Lamarckism#Epigenetic_LamarckismEva_Jablonka"><font colorspan style="#0000ff" size="2text-decoration: none; color: windowtext; text-underline: none" ><font face="맑은 고딕">http:Eva Jablonka<//en.wikipedia.org/wiki/Lamarckism#Epigenetic_Lamarckismfont></fontspan></a><font size="2" face="맑은 고딕">)and </font><o/span><span style="font-size:psmall"><a title="Marion J. Lamb" href="http://en.wikipedia.org/wiki/o:pMarion_J._Lamb"><span style="text-decoration: none; color: windowtext; text-underline: none"><font face="맑은 고딕">Marion J. Lamb</font></span></a><font face="맑은 고딕">. In addition to 'hard' or genetic inheritance, involving the duplication of genetic material and its segregation during </font></span><span style="font-size: small"><a title="Meiosis" href="http://en.wikipedia.org/wiki/Meiosis"><span style="text-decoration: none; color: windowtext; text-underline: none"><font face="맑은 고딕">meiosis</font></span></a><font face="맑은 고딕">, there are other hereditary elements that pass into the germ cells also. These include things like </font></span><span style="font-size: small"><a title="DNA methylation" href="http://en.wikipedia.org/wiki/DNA_methylation"><span style="text-decoration: none; color: windowtext; text-underline: none"><font face="맑은 고딕">methylation</font></span></a><font face="맑은 고딕"> patterns in DNA and </font></span></span><span style="font-size: small"><span lang="EN" style="mso-ansi-language: EN"><a title="Chromatin" href="http://en.wikipedia.org/wiki/Chromatin"><span style="text-decoration: none; color: windowtext; text-underline: none"><font face="맑은 고딕">chromatin</font></span></a><font face="맑은 고딕"> marks, both of which regulate the activity of genes </font></span></span><span lang="EN" style="mso-ansi-language: EN"><a href="http://en.wikipedia.org/wiki/Lamarckism#Epigenetic_Lamarckism"><span style="font-size: small"><font color="#0000ff" face="맑은 고딕">http://en.wikipedia.org/wiki/Lamarckism#Epigenetic_Lamarckism</font></span></a><span style="font-size: small"><font face="맑은 고딕">)</font></span><o:p></o:p></span></p><p><span style="font-size: small"><span lang="EN" style="mso-fareast-font-family: &quot;맑은 고딕&quot;; mso-fareast-theme-font: minor-latin; mso-bidi-font-family: &quot;맑은 고딕&quot;; mso-bidi-theme-font: minor-latin; mso-ansi-language: EN"><span style="mso-list: Ignore"><font face="맑은 고딕"><font face="Arial">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </font>7.</font><span style="font: 7pt &quot;Times New Roman&quot;">&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span><span lang="EN" style="mso-ansi-language: EN"><font face="맑은 고딕">Hydroxymethylation</font></span></span><span lang="EN" style="mso-ansi-language: EN"><font size="2"><font face="맑은 고딕"><o:p></o:p></font></font></span></p><p class="MsoListParagraph" style="margin: 0cm 0cm 8pt 38pt; mso-para-margin-left: 0gd"><span style="font-size: small"><span lang="EN" style="mso-ansi-language: EN"><font face="맑은 고딕">There is additional hydroxylation on methylated cytosine CpG.</font></span></span></p><p class="MsoListParagraph" style="margin: 0cm 0cm 8pt 38pt; mso-para-margin-left: 0gd"><span lang="EN" style="mso-ansi-language: EN"><o:p></o:p></span></p><p><span id="1433685821121E" style="display: none">&nbsp;</span></p>