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<li>what is epigenomics? set of modifications on a cell's DNA or histones. it largely ocnsists of DNA methylation, histone modification and RNAi affecting on gene expression, which is possible indirect genetic transmission. </li>
<li>Histone code : histone is representative of chromosomal protein coiling DNA compactly. Of course, its modification and combination influence the gene expression. Histones are acetylated/deacetylated, methylated/demethylated, phosphorylated/dephosphorylated, ubiquitinized, and sumoylated. sumoylation is attachment of SUMO(small ubiquitin-related modifier). sumoylation has some stimulation effect on HSF1 or p53, however, it is frequently used for repression through attenuation[12].</li>
<li>Technologies for studying epigenomics : a) bisulfate sequencing; DNA methylation is identified by this mehtod. when sodiumbisulfate is treated, only unmethylated cytosines undergoes deamination, converted into uracil, otherwise methylated cytosines are remained. such difference are shown by sequencing[13]. b) Chip-Seq : it identifies DNA-binding proteins(histones and transcription factor, for example) and detects binding sequence by NGS sequencing method. it is important to study chromatin packaging which is related to histone modification[14].</li>
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<p> -in the class</p><pul> <li>Is Darwinian evolution is correct?</li> </pul>
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<p>[10] http://www.the-scientist.com/?articles.view/articleNo/16879/title/Measuring-Protein-Concentrations-in-Live-Cells/</p>
<p>[11] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910158/</p>
<p> [12] http://www.pnas.org/content/100/23/13118.full</p><p>[13] http://blog.daum.net/kimuks/7532982</p><p> [14] http://blog.daum.net/kimuks/7533051</p>
