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From Biolecture.org
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<ul>
<li>Cleavage To trigger destruction of the mRNA strand into two pieces,</li> <li>Destabilization To interfere with translation of the mRNA through shortening of its poly(A) tail, and</li>
<li>Less efficient translation of the mRNA into proteins by ribosomes</li>
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<p>miRNAs resemble the small interfering RNAs (siRNAs) of the RNA interference (RNAi) pathway, except miRNAs derive from regions of RNA transcripts that fold back on themselves to form short hairpins, whereas siRNAs derive from longer regions of double-stranded RNA. The human genome may encode over 1000 miRNAs, which are abundant in many mammalian cell types and appear to target about 60% of the genes of humans and other mammals</p>
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<h1>Question</h1>
<h3>Can miRNA be available for a therapy about an intractable disease associated with a gene?</h3>
<p>Gene is the most central element to produce proteins in the body, and everything in human is determined by gene. and disease like a cancer is associated with the gene. If so i thought 'Can miRNA be available for a therapy about an intractable disease associated with a gene?'. Because miRNA can be specified target gene and interfere the translation of proteins by ribosome.</p>
<p>So answer is 'YES. miRNA can be available for a therapy'. Already many scientists are studying about these problem and the relationship between cancer and miRNA has been found.</p>
<p>but limitation and difficulties also exist. </p>
<p>first, Low permeation of miRNA by physical and physiological barriers of cancer tissue. Because abnormal vascular structure of tumor.</p>
<p>second, Unintended effects of miRNA. Because miRNAs target different pathways, unwanted gene suppression of cancer-suppressing genes may occur. This unintended effect may cause potential toxicity or reduce the effectiveness of the treatment.</p>
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<h1>Reference</h1>
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<p>https://en.wikipedia.org/wiki/MicroRNA#Target_prediction </p>
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<td style="width:50%">http://www.ibric.org/myboard/read.php?Board=report&id=2489</td>
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<td>molecular biology of the gene seventh edition-pearson</td>
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<td>http://www.kosen21.org/info/kosenReport/reportView.do?articleSeq=759471</td>
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