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<p>*PGE2(Prostaglandin E2)</p>
<p>-> Activate Prostaglandin receptor -> UCP1 Expression increase ->Adipose tissue transformation increase </p>
<p>*Increased Angiogenesis</p>
<p>=> Mobility of Targeted NPs to Adipose angiogenic vessel increase(Efficiency increase)</p>
<p> </p>
<p>(<a href="http://www.nature.com/nm/journal/v22/n7/full/nm0716-694.html">http://www.nature.com/nm/journal/v22/n7/full/nm0716-694.html</a>)</p>
<p>All in one: Researchers create combination drugs for diabetes and obesity</p>
<p> </p>
<p>Novelty of the combinations</p>
<p>-> Use protein engineering and chemistry</p>
<p>-> <u>Combine </u><u>two or more agents into a single molecule</u>.</p>
<p> </p>
<p>(1) GLP-1 Glucagon dual agonist</p>
<p>-> combine GLP-1(glucagon-like peptide 1) with Glucagon</p>
<p>-> Showed a nearly 5-pound weight loss in a dozen individuals</p>
<p>-> Suppress food intake</p>
<p>* Glucagon</p>
<p>-> Releases glucose into the bloodstream (unwise choice for an antidiabetic agent.)</p>
<p>-> Buffer the side effects of GLP-1 (when given in tandem)</p>
<p>-> the combination is more effective at lowering body weight than either of its components alone.</p>
<p> </p>
<p> </p>
<p> </p>
