Epigenomics-OG

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Epigenomics

 

"Epi">>reversible

 

definition : modifications on  DNA /histones

  • alter the DNA sequence

 

  • Tumorigenesis : cancer --> expression / regulation change

 

 

factor

  • DNA methylation
    • DNA methylase (DMNT)
    • effect
      • imprinting : transfer certain environmental factor
      • X-chromosome inactivation
      • Heterochromatin maintenance
      • Developmental controls
      • Tissue specific expression controls
    • How to sequence methylation?
      • Biosulfite treatment of cytosine : cytosine --> uracil ( 5-methylcytosine residues is unaffected)
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