Genomics-OG

1) Define Genomics your own way after doing research on what genomes are and how we study.

 

• It is about sequencing of DNA / mRNA / proteome and analyzing the function and structure of genome (especially whole genome in a cell or organism)
• difference from genetics : genetic study the detail of function or composition of a single gene whereas genomics cover all genes and their relationship.

 

 

2) What is the origin of genomics?

• genomics = gene + omics
• • gene =  locus of DNA containing genetic information which is mostly related to phenotype
  • omics = field of study in biology class >> proteomics ,metabolomics ,lipidomics , transcriptomics...

3) History of genomics?

• 1952 : helical structure of DNA (Rosaline Franklin)
• 1953 : structure of DNA ( James D, Watson , Francis Crick )
• 1955 : Amino acid sequence of insulin (Fred Sanger)
• 1964 : first nucleic acid sequence >> ribonucleotide sequence of alanine tRNA (Robert W.Holley)
• 1972 : gene sequence for Bacteriophage MS2 ( Walter Fiers) 

4) The future of genomics?

• Personal genomics
• • definition : sequencing individual genomes
  • why needed? every personal genome sequencing are different, so there may be some side effect from public drug or chemicals If certain person has specific gene sensitive to the drugs. personal genomics is able to carry genome sequencing from each person and by doing this, we can reach ideal drugs optimum to each person.
  • application (effect) : physiology / drugs / personal information of genetic disease / genetic variants

5) What is the relationship with other omics?

• functional genomics looks for the protein function and interaction, so they sometimes use transcriptomics or proteomics to know what kinds of function certain protein or transcriptome have 

6) How can we engineer genomes?

• modify genomic sequence --> repair mutated genes.

 

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Types of genomics

• Cognitive genomics : changes in cognitive processes
• Comparative genomics : study the relationship between structure and function
• Functional genomics : study of function and interaction of certain genomes
• Metagenomics : environmental genomics, study of genetic material recovered directly from environmental samples.
• Personal genomics : personalized genomics targeted for individual genome sequencing
• Epigenomics : set of epigenetic modification

 

effect

• gene-based understanding of complex biomolecules 
• study of intragenomic phenomena or their mutation

 

DNA-sequencing

• Plus and minus technique
• Sanger method
• Maxam-Gilbert method

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reference

1) http://www.journals.elsevier.com/genomics/

2) http://www.news-medical.net/life-sciences/What-is-Genomics.aspx

3) http://www.who.int/genomics/geneticsVSgenomics/en/

4) http://www.slideshare.net/pubudu/genomics