Il Young Cho

Principles of Bioinformatics

Bioinformatics is an interdisciplinary field of science which combines computer science, statistics, mathematics and engineering to study and process biological data.

Bioprogramming

2-1 Programming

Programming is a process that leads from an original formulation of a computing problem to executable computer programs. The purpose of programming is to find a sequence of instructions that will automate performing a specific task or solving a given problem.

2-2 Compiler

Compiler is a computer program that transforms source code written in a programming language into another computer language (binary form).

2-3 Language

There is some languages which we can use as a programming languages, such as C, R, Java, Perl and Matlab.

Genomics

3-1 What is Genomics?

Genomics is a discipline in genetics that applies recombinant DNA, DNA sequencing methods, and bioinformatics to sequence, assemble, and analyze the function and structure of genomes<o:p></o:p>

3-2 Origin, history and future of Genomics.

In 1975 Plus and Minus technique was developed. The refinement of the Plus and Minus method resulted in the chain-termination, or Sanger method which formed the basis of the techniques of DNA sequencing, genome mapping, data storage, and bioinformatic analysis most widely used in the following quarter-century of research. In the same year, the Maxam-Gilbert method was developed which is method of DNA sequencing. In the future, there will be more effective method to sequence DNA.<o:p></o:p>

 3-3 The English-language neologism omics informally refers to a field of study in biology ending in -omics, such as genomics, proteomics or metabolomics. The related suffix -ome is used to address the objects of study of such fields, such as the genome, proteome or metabolome respectively. The suffix -ome as used in molecular biology refers to a totality of some sort; similarly omics has come to refer generally to the study of large, comprehensive biological data sets. I think Genomics is fundamental study to other –omics such as proteomics or metabolomics, because technique or knowledge related to genomics is used to other studies to do experiment more efficiently.