Week7- Korean Genome Project, KPGP, KOREF
Korean Genome Project, KPGP, KOREF
20141215 jihoon moon
KPGP(korean personal genome project)
Project that goal is improvement of understanding korean individual genome and use these to research and development of bio industry. They want to find relationship between phenotype and diseases. So they needed for collect much things like rare-diseases, Korean’s various genome and feature of body.
It is a part of PGP (The international Personal Genome Project ). by U.S. none-profit research group, is founded in 2005 and seeking a diverse range of volunteers with the purpose of improving human health.
The Mission is to function as Korean center for PGP, to build a standard Korean genetic information database, to activate the participative genome research to develop genome sequencing and analysis technologies in the age of personal genetic information services and to establish an open community if sharing ethical, social, and legal issued in regard to genetic.
KOREF(korea standard reference genome map project)
Project that goal is generate Korean-specific genome structure with making korean standard reference genome map that are trustful in DNA array and composition.
For understanding Korean genome and genetic mutation distribution, we need the map of the standard reference genome and It is useful at epigenetic research, tailored personalized medicine or medical treatment, promotion of genome research, development of the biomedical industry as fundamental basic concept.
Now they mapping Korean Ref genome and compare to other known genomes(NCBI ref, YH(Chinese) and HuRef(venter)) , It is most important thing. Because comparing to others, we can find the Koreans’ own DNA information. The interesting thing in difference in SNP, the capsaicin associated protein-related mutation is common in 20 volunteers. This feature is shown in Korean’s spicy food cuisine. It may have a genetic basis for preference for spicy food.
They do Advances in genome assembly and phasing provide an opportunity to investigate the diploid architecture of the human genome and reveal the full range of structural variation across population groups. They report the de novo assembly and haplotype phasing of the Korean individual AK1 using single-molecule real-time sequencing, next-generation mapping, microfluidics-based linked reads, and bacterial artificial chromosome sequencing approaches. The de novo assembly that are useful analysis transcriptome along with local assemblies and spanning long reads,
Reference
http://kpgp.kr/index.php/Intro_01
http://koreagenome.kobic.re.kr/en/sub_3.html
https://www.youtube.com/results?search_query=korea+genome+project%2C+kpgp+%2Ckoref
http://opengenome.net/index.php/Main_Page
