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<p>MeCP2(Methyl CpG binding protein 2) - acts as a decoder. It only binds to the methylated CpG islands<sup>2)</sup> and recruits other 'switching off' proteins<sup>3)</sup>.</p>
<p>As a result, DNA is tightly packed and transcription factors cannot access to the promoter region</p>
<p>The methylation pattern is inherited to the daughter cells</p>
<p><img src="http://www.ks.uiuc.edu/Research/methylation/dna_mdna.png" />(http://www.ks.uiuc.edu/Research/methylation/dna_mdna.png)</p>
<p><img src="https://www.elitenetzwerk.bayern.de/uploads/tx_templavoila/Forschungsbericht_Epicombing_Zillner_figure1.jpg" />(https://www.elitenetzwerk.bayern.de/uploads/tx_templavoila/Forschungsbericht_Epicombing_Zillner_figure1.jpg)</p>
<p><img src="https://sites.tufts.edu/epigenetics/files/2014/11/methmaintenence1-e1418413999180.png" />(https://sites.tufts.edu/epigenetics/files/2014/11/methmaintenence1-e1418413999180.png)</p>
<p> </p>