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<p>When the gene switches off, the methylation level of the nearby CpG island is high.</p>
<p>MeCP2(Methyl CpG binding protein 2) - acts as a decoder. It only binds to the unmethylatedmethylated CpG islands.<sup>2)</sup>and recruits other 'switching off' proteins<sup>3)</sup>.</p>
<p><img src="http://www.ks.uiuc.edu/Research/methylation/dna_mdna.png" />(http://www.ks.uiuc.edu/Research/methylation/dna_mdna.png)</p>
<p>2) Meehan, Richard, Joe D. Lewis, and Adrian P. Bird. "Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA."<em>Nucleic acids research</em> 20.19 (1992): 5085-5092.</p>
<p>3) Nan, Xinsheng, et al. "Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex." <em>Nature</em> 393.6683 (1998): 386-389.</p>