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<pstyle="margin-left: 40px"><span style="color:#333333; font-family:arial,sans-serif; font-size:10pt"> Through the first lecture, I understand and think about the field of bioinformatics. First, I learned about definition of bioinformatics. From the beginning part of the lecture, I know that according to the parameter we use, world can be interpreted differently. Therefore, as Jong mentioned, biology is complex and bioinformatics interpret and study about this complex biological phenomenon by using different parameter. In other word, it is mapping the life, universe. </span></p>
<pstyle="margin-left: 40px"><span style="color:#333333; font-family:arial,sans-serif; font-size:10pt"> Second<strong>First, I learned about definition of bioinformatics. </strong>From the beginning part of the lecture, what is universe? Jong said I know that universe is according to the largest set of switches. I think that DNA can be some series of switches because it is composed of gene which parameter we use, world can be turn on and offinterpreted differently. Also Therefore, protein as Jong mentioned, biology is switch because it can be activated or inactivated complex and bioinformatics interpret and study about this complex biological phenomenon by using phosphorylation thorugh the upstream signaldifferent parameter. Upstream signal is also switch In other word, so it can be turn on and of. I think that it is infinite layers of switches, thereforemapping the life, I agree that the universe is the largest set of switches. </span></p>
<pstyle="margin-left: 40px"><span style="color:#333333; font-family:arial,sans-serif; font-size:10pt"><strong> ThirdSecond, I learned about brief history of biology. Dawin → Mendel → 3D proteins →what is universe? </strong>Jong said that DNA model → Sequencing → Cloning recombination → Amplification Technologies → Human reference genome → Next generation sequencing/personal genomics → Diagnostics using genomic data → Synthetic biology → Genome engineering → Cancer cure(2022) → Aging cure(2042)universe is the largest set of switches. I learned think that until the last decadeDNA can be some series of switches because it is composed of gene which can be turn on and off. Also, biology study was driven protein is switch because it can be activated or inactivated by structural studies such as protein foldingusing phosphorylation thorugh the upstream signal. Upstream signal is also switch, structural comparision, classification, molecular analysis and so it can be turn onand of. As technology and internet has developedI think that it is infinite layers of switches, people can easily share their datatherefore, so recent reserch shift toward sequence, databases, software, computation, and also function I agree that the universe is the largest set of proteinsswitches.</span></p>
<pstyle="margin-left: 40px"><span style="color:#333333; font-family:arial,sans-serif; font-size:10pt"><strong> ForthThird, I learned about major domain brief history of biology.</strong> Dawin → Mendel → 3D proteins → DNA model → Sequencing → Cloning recombination → Amplification Technologies → Human reference genome → Next generation sequencing/personal genomics → Diagnostics using genomic data → Synthetic biology → Genome engineering → Cancer cure(2022) → Aging cure(2042). I learned that until the last decade, biology study was driven by structural studies such as protein folding, structural comparision, classification, molecular analysis and so on. As technology and internet has developed, people can easily share their data, so recent reserch shift toward sequence, databases, software, computation, and also function of bioinformaticsproteins.</span></p>
<pstyle="margin-left: 40px"> <strong><span style="color:#333333; font-family:arial,sans-serif;font-size:10pt"> Sequence - GenomicsForth, I learned about major domain of bioinformatics.</span></strong></p>
<pul> <li>Sequence - Genomics</li> <li> Structure - Structural genomics, Structural proteomics, Biophysics</pli> <li>Expression - Functional genomics, proteomics</li> <li>Interaction – proteomics, interactomics</li> <li>Function – physiomics, metabolomics</li></ul>
<pstyle="margin-left: 40px"> In addition to this, there is sixth domain, network. Before I study about network, I leared about protein first. Protein has only 1000 different shape and superfaily, but they function Expression - Functional genomics, proteomicsso many different way. Those complexity and diversity is comes from the network of interaction as Jong said.</p>
<p> [[ Figure out the L-form of the amino acid ]]</p>