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Created page with "<p><span style="font-size:18px"><strong> Epigenomics - Epi(Outside) + Genomics(The study of genome, especially function and structure analysis)</strong></span></p> <ul> <l..."
<p><span style="font-size:18px"><strong> Epigenomics - Epi(Outside) + Genomics(The study of genome, especially function and structure analysis)</strong></span></p>
<ul>
<li>The study of the complete set of epigenetic modifications on the genetic material of a cell</li>
<li>Epigenetic modification</li>
</ul>
<ol>
<li>DNA methylation by DNMT (DNA methyltransferase)</li>
<li>Histone modification - acetylation, methylation, phosphorylation and so on</li>
</ol>
<ul>
<li>Epigenetic modifications play an important role in gene expression and regulation</li>
</ul>
<p> Ex) It could affect Tumorigenesis</p>
<p> Ex) DNA imprinting </p>
<ul>
<li><strong>The effects of chromatin structure on the function </strong>of the included genes</li>
<li>Chromatin structure</li>
</ul>
<ol>
<li>Euchromatin - a lightly packed form of chromatin. It is often under active transcription state.</li>
<li>Heterochromatin - a tightly packed form of chromatin - inaccessible to polymerase and not transcribed</li>
<li>Nucleosome - a basic unit of DNA packing in eukaryotes, consisting of 8 histone proteins and a segment of DNA (around 147bp)</li>
</ol>
<p> </p>
<ul>
<li>The study of the complete set of epigenetic modifications on the genetic material of a cell</li>
<li>Epigenetic modification</li>
</ul>
<ol>
<li>DNA methylation by DNMT (DNA methyltransferase)</li>
<li>Histone modification - acetylation, methylation, phosphorylation and so on</li>
</ol>
<ul>
<li>Epigenetic modifications play an important role in gene expression and regulation</li>
</ul>
<p> Ex) It could affect Tumorigenesis</p>
<p> Ex) DNA imprinting </p>
<ul>
<li><strong>The effects of chromatin structure on the function </strong>of the included genes</li>
<li>Chromatin structure</li>
</ul>
<ol>
<li>Euchromatin - a lightly packed form of chromatin. It is often under active transcription state.</li>
<li>Heterochromatin - a tightly packed form of chromatin - inaccessible to polymerase and not transcribed</li>
<li>Nucleosome - a basic unit of DNA packing in eukaryotes, consisting of 8 histone proteins and a segment of DNA (around 147bp)</li>
</ol>
<p> </p>