<p><b><span style="font-size: x-large">Principles of Bioinformatics</span></b></p>

<p>&nbsp; &nbsp;Threre are some example that use the word 'Bio Programming' as a technique in genetic engineering related to synthetic biology such as synthesizing or modifying biological object like DNA, proteins, or even cells. <a href="http://www.technologyreview.com/article/404707/bio-programming/">[1]</a><a href="http://aihub.net/bio-programming-hacking-dna-compiling-code-living-systems/">[2]</a>&nbsp;Therefore, to avoid confusion, the word 'Bioprogramming' written without blank would be limitted in meaning as programming in computer used to bioinformatics in 2015 1st semestser Bioinformatics class. Professor Bhak suggested following two examples:</p>

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<p style="margin-left: 40px">BioPerl is a collection of Perl modules that facilitate the development of Perl scripts for bioinformatics applications.&nbsp;<a href="http://en.wikipedia.org/wiki/BioPerl">http://en.wikipedia.org/wiki/BioPerl</a>&nbsp;</p>

<p>&nbsp; As shown in both examples, bioprogramming does not mean by the original programming language only for bioinformatics, but the use of existing general programming language such as Java<a href="http://www.ijcse.com/docs/INDJCSE11-02-06-087.pdf">[3]</a>&nbsp; or R<a href="http://cran.r-project.org/doc/contrib/Krijnen-IntroBioInfStatistics.pdf">[4]</a>&nbsp;specially for bioinformatics. There is &nbsp;even bioinformatics-specialized OS, <a href="http://environmentalomics.org/bio-linux/">Bio-Linux</a>, the Linux distribution&nbsp;with pakages of bioinformatics tools in OS level.</p>

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