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Personal genomics, bioinformatics, and variomics

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<font size="2">In 2009 and onwards, personal genome projects will produce unprecedented amount of biological data. New bioinformatics technologies will be required to handle them. New sequencing technologies will drive the next decades of biology and transform the medical practices in hospitals within the next decades. Fast sequencing unexpectedly brought us interesting applications such as metagenomics and ecogenomics. </font><font size="2">We have examined the current trends in genomics and variomics.</font><br />
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<div><strong><font size="2">Acknowledgements</font></strong><br />
SK was supported by Soongsil University Reserach Fund.<br />
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<div><font size="2"><strong>References</strong></font></div>
<div style="MARGIN: 0cm 0cm 0pt 36pt; TEXT-INDENT: -36pt"><font size="2">IHGSC (2004). Finishing the euchromatic sequence of the human genome. <em>Nature</em> <strong>431</strong>(7011), 931-45.</font></div><div style="MARGIN: 0cm 0cm 0pt 36pt; TEXT-INDENT: -36pt"><font size="2">Anderson, S., A. T. Bankier, <em>et al. </em> (1981). Sequence and organization of the human mitochondrial genome. <em>Nature</em> <strong>290</strong>(5806), 457-65.</font></div><div style="MARGIN: 0cm 0cm 0pt 36pt; TEXT-INDENT: -36pt"><font size="2">Chan, E. Y. (2005). Advances in sequencing technology. <em>Mutat . Res.</em> <strong>573</strong>(1-2), 13-40.</font></div><div style="MARGIN: 0cm 0cm 0pt 36pt; TEXT-INDENT: -36pt"><font size="2">Church, G. M. (2005). The personal genome project. <em>Mol . Syst . Biol.</em> 1<strong>1,</strong> 2005.0030.</font></div><div style="MARGIN: 0cm 0cm 0pt 36pt; TEXT-INDENT: -36pt"><font size="2">Gupta, P. K. (2008). Single-molecule DNA sequencing technologies for future genomics research. <em>Trends Biotechnol.</em> <strong>26</strong>(11), 602-11.</font></div><div style="MARGIN: 0cm 0cm 0pt 36pt; TEXT-INDENT: -36pt"><font size="2">Kim, T-M. <em>et al. </em> (2008). &quot;Copy Number Variations in the Human Genome: Potential Source for Individual Diversity and Disease Association Studies.<em>Genomics &amp; Informatics</em>&quotnbsp; 6(1): , 1-7.</font></div><div style="MARGIN: 0cm 0cm 0pt 36pt; TEXT-INDENT: -36pt"><font size="2">Levy, S., G. Sutton, <em>et al</em>. (2007). The diploid genome sequence of an individual human. <em>PLoS Biol.</em> <strong>5</strong>(10), e254.</font></div><div style="MARGIN: 0cm 0cm 0pt 36pt; TEXT-INDENT: -36pt"><font size="2">Mardis, E. R. (2008). The impact of next-generation sequencing technology on genetics. <em>Trends Genet.</em> <strong>24</strong>(3), 133-41.</font></div><div style="MARGIN: 0cm 0cm 0pt 36pt; TEXT-INDENT: -36pt"><font size="2">Metzker, M. L. (2005). Emerging technologies in DNA sequencing. <em>Genome Res.</em> <strong>15</strong>(12), 1767-76.</font></div><div style="MARGIN: 0cm 0cm 0pt 36pt; TEXT-INDENT: -36pt"><font size="2">Park, H. <em>et al</em>. (2008). Genome-wide Linkage Study for Plasma HDL Cholesterol Level in an Isolated Population of Mongolia. <em>Genomics &amp; Informatics </em> 6(1): , 8-13.</font></div><div style="MARGIN: 0cm 0cm 0pt 36pt; TEXT-INDENT: -36pt"><font size="2">Porreca, G. J., J. Shendure, <em>et al</em>. (2006). Polony DNA sequencing. <em>Curr Protoc . Prot. Mol . Biol.</em> <strong>Chapter 7</strong>: Unit 7 8.</font></div><div style="MARGIN: 0cm 0cm 0pt 36pt; TEXT-INDENT: -36pt"><font size="2">Ring, H. Z., P. Y. Kwok, <em>et al</em>. (2006). Human Variome Project: an international collaboration to catalogue human genetic variation. <em>Pharmacogenomics</em> <strong>7</strong>(7), 969-72.</font></div><div style="MARGIN: 0cm 0cm 0pt 36pt; TEXT-INDENT: -36pt"><font size="2">Sanger, F., G. M. Air, <em>et al</em>. (1977). Nucleotide sequence of bacteriophage phi X174 DNA. <em>Nature</em> <strong>265</strong>(5596), 687-95.</font></div><div style="MARGIN: 0cm 0cm 0pt 36pt; TEXT-INDENT: -36pt"><font size="2">Shendure, J., R. D. Mitra, <em>et al</em>. (2004). Advanced sequencing technologies: methods and goals. <uem>Nat.</uem> <em>Rev . Genet.</em> <strong>5</strong>(5), 335-44.</font></div><div style="MARGIN: 0cm 0cm 0pt 36pt; TEXT-INDENT: -36pt"><font size="2">Sung, J. et al. (2008). &quot;Inbreeding Coefficients in Two Isolated Mongolian Populations - GENDISCAN Study.' <em>Genomics &amp; Informatics </em> 6(1): 14-17.</font></div><div style="MARGIN: 0cm 0cm 0pt 36pt; TEXT-INDENT: -36pt"><font size="2">Wheeler, D. A., M. Srinivasan, <em>et al</em>. (2008). The complete genome of an individual by massively parallel DNA sequencing. <em>Nature</em> <strong>452</strong>(7189), 872-6.</font></div>
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