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<p><span style="color: #000000"><i><b>Mycoplasma genitalium</b></i> is a small parasitic bacterium which lives on the ciliated epithelial cells of the primate genital and respiratory tracts. <i>M. genitalium</i> is the smallest known free-living bacterium, and the second-smallest bacterium after the recently-discovered endosymbiont <i>Carsonella ruddii</i>. Until the discovery of <i>Nanoarchaeum</i> in 2002, <i>M. genitalium</i> was also considered to be the organism with the smallest genome.<sup id="cite_ref-0" class="reference"><font size="2">[1]</font></sup></span></p>
<p><table id="toc" class="toc"> <tbody> <tr> <td> <div id="toctitle"> <h2><span style="color: #000000">Contents</span></h2> <span style="color: #000000"><span class="toctoggle"><font size="2">[</font><font size="2">hide</font><font size="2">]</font></span></span></div> <ul> <li class="toclevel-1 tocsection-1"><span style="color: #000000"><span class="tocnumber">1</span> <span class="toctext">Overview</span></span></li> <li class="toclevel-1 tocsection-2"><span style="color: #000000"><span class="tocnumber">2</span> <span class="toctext">Symptoms</span></span></li> <li class="toclevel-1 tocsection-3"><span style="color: #000000"><span class="tocnumber">3</span> <span class="toctext">Treatment</span></span></li> <li class="toclevel-1 tocsection-4"><span style="color: #000000"><span class="tocnumber">4</span> <span class="toctext">Synthetic life</span></span></li> <li class="toclevel-1 tocsection-5"><span style="color: #000000"><span class="tocnumber">5</span> <span class="toctext">See also</span></span></li> <li class="toclevel-1 tocsection-6"><span style="color: #000000"><span class="tocnumber">6</span> <span class="toctext">References</span></span></li> <li class="toclevel-1 tocsection-7"> </li> </ul> </td> </tr> </tbody></table><span style="color: #000000"></span></p>
<h2><span style="color: #000000"><span id="Overview" class="mw-headline">Overview</span></span></h2>
<p><span style="color: #000000"><i>Mycoplasma genitalium</i> was originally isolated in 1980 from urethral specimens of two male patients with non-gonococcal urethritis. Infection by <i>M. genitalium</i> seems fairly common, can be transmitted between partners during unprotected sexual intercourse, and can be treated with antibiotics; however, the organism's role in genital diseases is still unclear.</span></p>
<ol class="references">
<li id="cite_note-0"><b><a href="#cite_ref-0"><font color="#0645ad">^</font></a></b> Aside from <a title="Virus" href="/wiki/Virus"><font color="#0645ad">viruses</font></a>—however, it is not agreed upon whether or not viruses constitute life.</li>
<li id="cite_note-1"><b><a href="#cite_ref-1"><font color="#0645ad">^</font></a></b> <span class="citation Journal">Fraser, Claire M.; <i>et al.</i> (1995). "The Minimal Gene Complement of Mycoplasma genitalium". <i>Science</i> <b>270</b> (5235): 397–404. <a title="Digital object identifier" href="/wiki/Digital_object_identifier"><font color="#0645ad">doi</font></a>:<a class="external text" rel="nofollow" href="http://dx.doi.org/10.1126%2Fscience.270.5235.397" rel="nofollow"><font color="#3366bb">10.1126/science.270.5235.397</font></a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Minimal+Gene+Complement+of+Mycoplasma+genitalium&rft.jtitle=Science&rft.aulast=Fraser&rft.aufirst=Claire+M.&rft.au=Fraser%2C%26%2332%3BClaire+M.&rft.date=1995&rft.volume=270&rft.issue=5235&rft.pages=397%E2%80%93404&rft_id=info:doi/10.1126%2Fscience.270.5235.397&rfr_id=info:sid/en.wikipedia.org:Mycoplasma_genitalium"><span style="display: none"> </span></span></li> <li id="cite_note-2"><b><a href="#cite_ref-2"><font color="#0645ad">^</font></a></b> <a class="external free" rel="nofollow" href="http://www.cdc.gov/std/treatment/2006/urethritis-and-cervicitis.htm#uc2" rel="nofollow"><font color="#3366bb">http://www.cdc.gov/std/treatment/2006/urethritis-and-cervicitis.htm#uc2</font></a></li> <li id="cite_note-3"><b><a href="#cite_ref-3"><font color="#0645ad">^</font></a></b> <span class="citation news">Pilkington, Ed (2007-10-06). <a class="external text" rel="nofollow" href="http://www.guardian.co.uk/science/2007/oct/06/genetics.climatechange" rel="nofollow"><><font color="#3366bb">"I am creating artificial life, declares US gene pioneer"</font></a>. <i><a title="The Guardian" href="/wiki/The_Guardian"><font color="#0645ad">The Guardian</font></a></i><span class="printonly">. <a class="external free" rel="nofollow" href="http://www.guardian.co.uk/science/2007/oct/06/genetics.climatechange" rel="nofollow"><font color="#3366bb">http://www.guardian.co.uk/science/2007/oct/06/genetics.climatechange</font></a></span>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=I+am+creating+artificial+life%2C+declares+US+gene+pioneer&rft.jtitle=%5B%5BThe+Guardian%5D%5D&rft.aulast=Pilkington&rft.aufirst=Ed&rft.au=Pilkington%2C%26%2332%3BEd&rft.date=2007-10-06&rft_id=http%3A%2F%2Fwww.guardian.co.uk%2Fscience%2F2007%2Foct%2F06%2Fgenetics.climatechange&rfr_id=info:sid/en.wikipedia.org:Mycoplasma_genitalium"><span style="display: none"> </span></span></li> <li id="cite_note-4"><b><a href="#cite_ref-4"><font color="#0645ad">^</font></a></b> <span class="citation news">Briggs, Helen (2008-01-24). <a class="external text" rel="nofollow" href="http://news.bbc.co.uk/1/hi/sci/tech/7203186.stm" rel="nofollow"><font color="#3366bb">"Synthetic life 'advance' reported"</font></a>. <i><a title="BBC News" href="/wiki/BBC_News"><font color="#0645ad">BBC News</font></a></i><span class="printonly">. <a class="external free" hrefrel="nofollow" href="http://news.bbc.co.uk/1/hi/sci/tech/7203186.stm" rel="nofollow"><font color="#3366bb">http://news.bbc.co.uk/1/hi/sci/tech/7203186.stm</font></a></span>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Synthetic+life+%27advance%27+reported&rft.jtitle=%5B%5BBBC+News%5D%5D&rft.aulast=Briggs&rft.aufirst=Helen&rft.au=Briggs%2C%26%2332%3BHelen&rft.date=2008-01-24&rft_id=http%3A%2F%2Fnews.bbc.co.uk%2F1%2Fhi%2Fsci%2Ftech%2F7203186.stm&rfr_id=info:sid/en.wikipedia.org:Mycoplasma_genitalium"><span style="display: none"> </span></span></li> <li id="cite_note-5"><b><a href="#cite_ref-5"><font color="#0645ad">^</font></a></b> <span class="citation news">Ball, Philip (2008-01-24). <a class="external text" rel="nofollow" href="http://www.nature.com/news/2008/080124/full/news.2008.522.html" rel="nofollow"><font color="#3366bb">"Genome stitched together by hand"</font></a>. <i>Nature News</i>. <a title="Digital object identifier" href="/wiki/Digital_object_identifier"><font color="#0645ad">doi</font></a>:<a class="external text" rel="nofollow" href="http://dx.doi.org/10.1038%2Fnews.2008.522" rel="nofollow"><font color="#3366bb">10.1038/news.2008.522</font></a><span class="printonly">. <a class="external free" rel="nofollow" href="http://www.nature.com/news/2008/080124/full/news.2008.522.html" rel="nofollow"><font color="#3366bb">http://www.nature.com/news/2008/080124/full/news.2008.522.html</font></a></span>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genome+stitched+together+by+hand&rft.jtitle=Nature+News&rft.aulast=Ball&rft.aufirst=Philip&rft.au=Ball%2C%26%2332%3BPhilip&rft.date=2008-01-24&rft_id=info:doi/10.1038%2Fnews.2008.522&rft_id=http%3A%2F%2Fwww.nature.com%2Fnews%2F2008%2F080124%2Ffull%2Fnews.2008.522.html&rfr_id=info:sid/en.wikipedia.org:Mycoplasma_genitalium"><span style="display: none"> </span></span></li>
<li id="cite_note-wiredlife-6"><b><a href="#cite_ref-wiredlife_6-0"><font color="#0645ad">^</font></a></b> <span class="citation web">Swaby, Rachel. [On 20 May 2010 they report success with the implantation of th "Scientists Create First Self-Replicating Synthetic Life"]. Wired<span class="printonly">. On 20 May 2010 they report success with the implantation of th</span><span class="reference-accessdate">. Retrieved 21 May 2010</span>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.btitle=Scientists+Create+First+Self-Replicating+Synthetic+Life&rft.atitle=&rft.aulast=Swaby&rft.aufirst=Rachel&rft.au=Swaby%2C%26%2332%3BRachel&rft.pub=Wired&rft_id=On+20+May+2010+they+report+success+with+the+implantation+of+th&rfr_id=info:sid/en.wikipedia.org:Mycoplasma_genitalium"><span style="display: none"> </span></span></li>
</ol>
<h2><span id="External_links" class="mw-headline">External links</span></h2>
<ul>
<li><a class="external text" rel="nofollow" href="http://www.hpa.org.uk/cfi/stbrl/Mycoplasma_genitalium_ref_work.htm" rel="nofollow"><font color="#3366bb">Mycoplasma genitalium Reference Work</font></a> at the <a class="mw-redirect" title="UK Health Protection Agency" href="/wiki/UK_Health_Protection_Agency"><font color="#0645ad">UK Health Protection Agency</font></a></li> <li><a class="external text" rel="nofollow" href="http://cmr.jcvi.org/tigr-scripts/CMR/GenomePage.cgi?database=gmg" rel="nofollow"><font color="#3366bb">Mycoplasma genitalium G-37 genome page</font></a></li>
</ul>