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<p>[[Sungbin Lim]]</p>
<p>1. What is history of life?<br />
2. How does adaption evolve?</p>
<p>quesiton of evolution<br />
1. What is necessary to make a new species?<br />
- How many genes?<br />
How much of the genome needs to diverge in order to create a new species?<br />
- What type of genes?<br />
What sort of genes/genomic regions are contained within 'highly divergent part of the genome'?<br />
- Where are they located in the genome?<br />
2. Denovo evolution or standing variation?</p>
<p>3. Pathogen can be clues to detect evolution. Malaria in Human evolution.<br />
- Malaria study in natural selection.<br />
- Characterize genomic variation. Search for signals of genome evolution<br />
- Sequence drug resistance strain. Figure out where are most diverse region. -> 논문 : Variation data reveals drug resistance genes</p>
<p><br />
Conclusion<br />
1. More data+genome sequencing is helping to resolve fundamental questions in evolutionary biology<br />
- Phylogenetic relationships<br />
- Evolution of adaptive traits<br />
- Human evolution/ demography<br />
2. New problems<br />
- Function of adaptive loci<br />
- Demographic methods<br />
- Lots of data</p>
<p><br />
How can 16S RNA sequencing being central method of identifying species in microbiome?<br />
</p>