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<p><span style="font-size:14px"><strong>Lecture 3 - Genomics</strong></span></p>
<p>* What is <u>Genomics</u>?<br />
- After assmbling genome of one species, we can use it as reference genome.<br />
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► MRCA : most recent common ancestor -> we can predictsimilarity between different species.</p> <hr /><p> </p> <p> </p> <p>** Summary **</p> <p>(1) Genomics is changing the paradigm of biology.<br />(2) Geno-Pheno associated mutation is the key.<br />(3) Close species provide exact variants for pin-pointing mutation sites.<br />(4) Efficient reference to resequencing data comparison will be a useful bioinformatics methodology.<br /><br /><br /> </p> <hr /><p><strong><span style="font-size:14px">Presentation 1. "5<sup>th</sup> generation sequencing"</span></strong></p> <p>► Design own model of sequencing.</p> <p>► Idea<br /> (1) different H-bond of bases -> nanosensor based on DNA helicase -> sort AT, GC base pairing + measure change of current based on difference of size (pyrimidine vs. purine)<br /> (2) detect decresing ATP, incresing ADP, and Pi.<br /> (3) using dsDNA -> break bond -> sequencing</p>