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<p> </p>
<p><a href="https://www.ncbi.nlm.nih.gov/pubmed/27140638">https://www.ncbi.nlm.nih.gov/pubmed/27140638</a></p>
<p>(Preventing diet-induced obesity in mice by adipose tissue transformation and angiogenesis using targeted nanoparticles.)</p>
<p>*Rosi ->PPAR activity increase</p>
<p>(1)Expression of uncoupling protein(UCP1) increase</p>
<p>-> Transformation (WAT->Brown-like adipose tissue) & Angiogenesis increase</p>
<p>(2) Expression of VEGF& Angiopoietin-like 4 increase</p>
<p>-> Adipose tissue angiogenesis increase</p>
<p>*PGE2(Prostaglandin E2)</p>
<p>-> Activate Prostaglandin receptor -> UCP1 Expression increase ->Adipose tissue transformation increase </p>
<p>*Increased Angiogenesis</p>
<p>=> Mobility of Targeted NPs to Adipose angiogenic vessel increase(Efficiency increase)</p>
<p> </p>