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Dabeen Park/Question

15 bytes added, 23:28, 15 December 2017
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<p>&nbsp; &nbsp;the second fragment start from first ATG, but that is not triple size.</p>
 
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<p>A : &quot;After the replication fork has passed by, the lagging strand is left as a series of&nbsp;Okazaki fragments&nbsp;with&nbsp;gaps&nbsp;(i.e., spaces from which one or more nucleotides are missing) between them. In addition, there are short pieces of RNA primer alternating with newly-synthesized DNA. Joining the&nbsp;Okazaki fragments&nbsp;to give a complete strand of DNA is accomplished by two&mdash;or perhaps three&mdash;enzymes working in&nbsp;succession:&nbsp;Ribonuclease H(RNase H),&nbsp;DNA polymerase I&nbsp;(Pol I), and&nbsp;DNA ligase. Only the last two enzymes are involved in the classical model. DNA polymerase I degrades the RNA primers and fills the resulting gaps. Finally, DNA ligase joins the sugar phosphate backbone (Fig. 10.13). In an alternate model, RNase H, which typically degrades the RNA strand of DNA:RNA double helixes, removes most of each RNA primer and DNA polymerase I only removes the last few bases of the RNA primers.&quot;</p>
<p>Reference : David P.&nbsp;Clark,&nbsp;Nanette J.&nbsp;Pazdernik, in&nbsp;Molecular Biology (Second Edition),&nbsp;2013&nbsp;Cell Division and DNA Replication</p>
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