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About sequencing

289 bytes added, 20:39, 4 October 2017
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<p><span style="color:#000000">In genomics, sequencing is to determine the arrangement&nbsp;</span><span style="color:#000000">of DNA. </span>Sequencing is consist of methods are&nbsp;outlined with&nbsp;three basic steps as outlined shown below.</p>
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<p><span style="color:#000000">A&nbsp;genomic library&nbsp;is a collection of the total genomic DNA</span><span style="color:#000000">&nbsp;from a single&nbsp;organism</span><span style="color:#000000">. The DNA is stored in a population of identical vectors,</span><span style="color:#000000">&nbsp;each containing a different insert&nbsp;</span><span style="color:#000000">of DNA. In order to construct a genomic library, the organism&#39;s DNA is extracted&nbsp;</span><span style="color:#000000">from cells&nbsp;</span><span style="color:#000000">and then digested with a restriction enzyme&nbsp;to cut the DNA into fragments of a specific size. (above definition is by https://en.wikipedia.org/wiki/Genomic_library)</span></p>
<p><font color="#000000">Fragments made by restriction enzyme undergo additional process, such as ligation of adaptor and primer, which let them&nbsp;be able to function in next phase.</font></p>
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<h2>emPCR</h2>
 
<p><img alt="" src="/ckfinder/userfiles/images/emPCR%2C%20Solid-phase%20amplification%20(2).png" style="height:183px; width:731px" /></p>
 
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<h2>Solid-phase</h2>
 
<p><img alt="" src="/ckfinder/userfiles/images/emPCR%2C%20Solid-phase%20amplification%20(3).png" style="height:285px; width:478px" /></p>
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