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Contents: 1.Abstract 2.Introduction 3.The problem 4.My idea 5.The details 6.Related works 7.References

According to outcome, 21 amino acid changes in VEGF co regulated chemokine 1 were observed, among them 12 amino acid had non-synonymous variation.  These modifications could lead to specific features to the angiogenesis. There are also more proteins that responsible to new vessel formation in organism. So further research indeed necessary.

Related works:

References:

[1]  <cite>Rugh, David J.; Shelden, Kim E. W. (2008). "Bowhead Whale". In Perrin, William F.;</cite> <cite><a href="https://en.wikipedia.org/wiki/Bernd_W%C3%BCrsig" title="Bernd Würsig">Würsig, Bernd</a></cite><cite>; Thewissen, J. G. M.</cite> <cite>Encyclopedia of Marine Mammals</cite> <cite>(Second ed.). </cite><cite>Academic Press. p. 131.</cite> <cite><a href="https://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number">ISBN</a> <a href="https://en.wikipedia.org/wiki/Special:BookSources/978-0-12-373553-9" title="Special:BookSources/978-0-12-373553-9">978-0-12-373553-9</a>.</cite>

[2] Michael Keane, Jeremy Semeiks “Insights into the Evolution of Longevity from the Bowhead Whale Genome” Published: December 24, 2014 in Cell reports

<a href="http://www.cell.com/cell-reports/abstract/S2211-1247(14)01019-5">http://www.cell.com/cell-reports/abstract/S2211-1247(14)01019-5</a>

[3] Gatesy, J., Geisler, J.H., Chang, J., Buell, C., Berta, A., Meredith, R.W., Springer, M.S., and McGowen, M.R. (2013). A phylogenetic blueprint for a modern whale. Mol. Phylogenet. Evol. 66, 479–506.

[4] Tacutu, R., Craig, T., Budovsky, A., Wuttke, D., Lehmann, G., Taranukha, D., Costa, J., Fraifeld, V.E., and de Magalha&tilde; es, J.P. (2013). Human Ageing Genomic Resources: integrated databases and tools for the biology and genetics of ageing. Nucleic Acids Res. 41, D1027–D1033.

[5] Gilkes, Daniele M., Gregg L. Semenza, and Denis Wirtz. "Hypoxia and the extracellular matrix: drivers of tumour metastasis." Nature Reviews Cancer 14.6 (2014): 430-439.

[6] Daniel Weber “Cell hypoxia: The Prime cause of Cancer on Cell level” posted to complementary oncology website in November 2, 2011.

<a href="http://complementaryoncology.com/reports/others/cell-hypoxia-the-prime-cause-of-cancer-on-cell-level/">http://complementaryoncology.com/reports/others/cell-hypoxia-the-prime-cause-of-cancer-on-cell-level/</a>

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<h2>[7] <a href="http://www.jle.com/fr/recherche/recherche.phtml?dans=auteur&texte=Christiane+Brahimi-Horn">Christiane Brahimi-Horn</a>, <a href="http://www.jle.com/fr/recherche/recherche.phtml?dans=auteur&texte=Jacques+Pouyss%C3%A9gur+">Jacques Pouysségur</a> “The role of the hypoxia-inducible factor in tumor metabolism growth and invasion”. Published in 2006 on <a href="https://www.google.co.kr/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0ahUKEwiy1Ljl4dTQAhVLTbwKHXasC0oQjhwIBQ&url=http%3A%2F%2Fwww.jle.com%2Ffr%2Frevues%2Fbdc%2Fe-docs%2Fthe_role_of_the_hypoxia_inducible_factor_in_tumor_metabolism_growth_and_invasion_269705%2Farticle.phtml%3Ftab%3Dimages&bvm=bv.139782543,d.dGc&psig=AFQjCNHOAtqOfUdlhbjU4ER9GFPRkQmsag&ust=1480742493553300" target="_blank">John Libbey Eurotext</a> websit <a href="http://www.jle.com/fr/revues/bdc/e-docs/the_role_of_the_hypoxia_inducible_factor_in_tumor_metabolism_growth_and_invasion_269705/article.phtml">http://www.jle.com/fr/revues/bdc/e-docs/the_role_of_the_hypoxia_inducible_factor_in_tumor_metabolism_growth_and_invasion_269705/article.phtml</a></h2>

<h2>[8] Harris AL, “Hypoxia: a key regulatory factor in tumor growth”, National Review in Cancer 2002 January; 2(1): p. 38-47.</h2>

<h2>[9] Sequence details CXCL17 bmy_22314 (Coding sequence)</h2>

<h2><a href="http://www.bowhead-whale.org/annotations/details/bmy_22314/">http://www.bowhead-whale.org/annotations/details/bmy_22314/</a></h2>

<h2>VEGF co-regulated chemokine 1 precursor (Human) <a href="https://www.ncbi.nlm.nih.gov/protein/NP_940879">https://www.ncbi.nlm.nih.gov/protein/NP_940879</a></h2>

<h2>Homo sapiens C-X-C motif chemokine ligand 17 (CXCL17) <a href="https://www.ncbi.nlm.nih.gov/nuccore/NM_198477">https://www.ncbi.nlm.nih.gov/nuccore/NM_198477</a></h2>

<h2>[10] Blast results:  <a href="https://blast.ncbi.nlm.nih.gov/Blast.cgi">https://blast.ncbi.nlm.nih.gov/Blast.cgi</a></h2>

<h2>[11] Shih T, Lindley C. Bevacizumab: an angiogenesis inhibitor for the treatment of solid malignancies. Clinical Therapeutics 2006; 28(11):1779–1802. </h2>

<h2>[12] Gotink KJ, Verheul HM. Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action? Angiogenesis 2010</h2>

<h2>[13] By Melissa Hogenboom “The animal that does not get cancer” on BBC website, posted 31 October 2015 <a href="http://www.bbc.com/earth/story/20151031-the-animal-that-doesnt-get-cancer">http://www.bbc.com/earth/story/20151031-the-animal-that-doesnt-get-cancer</a></h2>

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