Canceromics and Geromics Class, 180608

Presentation about ‘Canceromics and Geromics’

-What is Canceromics?

 

-Why is it so difficult to cure cancer?

Cancer is a multi-step disease.

Cancers are clonal and heterogenic, so it is not easy to target one gene.

 

-How can we find potential drug targets for cancer?

Single cell sequencing

Application : Precision medicine

 

-What is Geromics?

 

-Introduction of Geromics Inc.

Geromics technologies

Business scope : Personal Genomics, Telomere

 

-What is telomere and telomerase?

 

-How can we measure telomere length?

FISH(fluorescent in situ hybridization) – measured by light intensity, precise method for measurement, expensive

*in situ : ‘on site’ or ‘in position’

 

-How many nucleotides are shortened in each cell division?

My answer is

Original telomere length : 15,000 nucleotides

(6 nucleotides are repeated approximately 2,500 times)

Remaining telomere length after cell divisions : 5,000 nucleotides

---------------------------------------------------------------------------------------

Telomere length shortened by cell divisions : 10,000 nucleotides

 

Somatic cells usually divide up to 50~70 times

 

Therefore, 10,000 nucleotides / 50~70 times = 150~200 nucleotides are shortened in each cell division.

 

 

<Presentation by Sungbin and Juhyeon : Host transmission of a MERS CoV genome>

 My question

-Why did they select a MERS CoV genome, even though camel is not familiar to Korean?

MERS CoV genome is only in humans and camel, and it is infected to Korean.

 

-Why did they divide three variations: time, host, and region?

It is by isolation from GB data.

 

*ORF : open reading frame

 

 

<Lecture by Jong>

-Aging is a disease?

I think aging is a disease.

 

-What is a difference between aging and cancer?

Aging is already programmed, but cancer is accident.

 

-Why do we age?

 

-A study of Aging by bioinformatics

Comparison of young genome and old genome

Genome analysis of people who live longer more than 100 years

reversing epigenetic change by using CRISPR-Cas9

Female diver(해녀) have a certain bone structure.

 

-Genomics & Epigenomics

 

*pneumonia: 폐렴