Epigenomics-OG
Revision as of 10:45, 19 June 2016 by imported>Gun Oh (Created page with "<p>Epigenomics</p> <p> </p> <p>"Epi">>reversible</p> <p> </p> <p>definition : modifications on DNA /histones</p> <ul> <li>alter the DNA ...")
"Epi">>reversible
definition : modifications on DNA /histones
- alter the DNA sequence
- Tumorigenesis : cancer --> expression / regulation change
factor
- DNA methylation
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- DNA methylase (DMNT)
- effect
-
- imprinting : transfer certain environmental factor
- X-chromosome inactivation
- Heterochromatin maintenance
- Developmental controls
- Tissue specific expression controls
- How to sequence methylation?
-
- Biosulfite treatment of cytosine : cytosine --> uracil ( 5-methylcytosine residues is unaffected)