Restless legs syndrome

GENE: RLS1
CYTO: 12q12-q21
DESC: Restless legs syndrome, susceptibility to, 1
SNP : rs2300478

In a genomewide association study of 393 RLS patients and 1602 controls,
Winkelmann et al. (2007) found a significant association between RLS and
dbSNP rs2300478 in the MEIS1 gene (601739). The findings were confirmed
in 2 independent replication studies of 875 and 211 patients,
respectively. Combined results of all 3 studies yielded an overall odds
ratio of 1.74 for the G allele (p = 8.08 x 10(-23)). The study also
showed evidence for an association with several SNPs within a region on
chromosome 15q that contains the LBXCOR1 (611273) and MAP2K5 (602520)
genes.

Reference
Winkelmann, J.; Schormair, B.; Lichtner, P.; Ripke, S.; Xiong, L.; Jalilzadeh, S.; Fulda, S.; Putz, B.; Eckstein, G.; Hauk, S.; Trenkwalder, C.; Zimprich, A.; and 15 others :

Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nature Genet. 39: 1000-1006, 2007. PubMed ID : 17637780