Jihwan Jeon/scientific essay

Expanding genetic code for unstable non-canonical amino acids by using stop codon suppression technique

20141541 Jihwan Jeon

 

Introduction

The genetic code of all organisms encodes just 20 common amino acids. However, these 20 amino acids, canonical amino acids, can be modified by post-translation modification(PTM) process. Through the PTM tons of various amino acids are formed and they have their own important chemical biological functions in organism.

Among those PTM, some of PTM’s function was still not discovered well. One example of that is N-phosphorylation. N-phosphorylation means phosphorylation to N group in side chain of His, Lys or Arg. Those N-phosphorylation was still quite not explored because of its low stability in N-phosphate bond.

DNA sequences are transcripted to mRNA and then translated to amino acids. During the translation, each three mRNA sequence is assigned to specific amino acid. In 2001, one interesting

 

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