Difference between revisions of "Proteomics BIO431SB"
From Biolecture.org
imported>SaetByeol-Kim |
imported>SaetByeol-Kim |
||
| Line 10: | Line 10: | ||
<p> <span style="white-space: normal; word-spacing: 0px; text-transform: none; float: none; color: rgb(77,77,77); text-align: left; font: 12px/18px Arial, sans-serif; widows: 1; display: inline !important; letter-spacing: normal; background-color: rgb(255,255,255); text-indent: 0px; -webkit-text-stroke-width: 0px">he term<span class="Apple-converted-space"> </span></span><b style="border-top: 0px; border-right: 0px; vertical-align: baseline; white-space: normal; word-spacing: 0px; border-bottom: 0px; text-transform: none; color: rgb(77,77,77); padding-bottom: 0px; text-align: left; padding-top: 0px; font: 900 12px/18px Arial, sans-serif; padding-left: 0px; margin: 0px; border-left: 0px; widows: 1; letter-spacing: normal; padding-right: 0px; background-color: rgb(255,255,255); text-indent: 0px; -webkit-text-stroke-width: 0px; font-stretch: inherit">"proteome"</b><span style="white-space: normal; word-spacing: 0px; text-transform: none; float: none; color: rgb(77,77,77); text-align: left; font: 12px/18px Arial, sans-serif; widows: 1; display: inline !important; letter-spacing: normal; background-color: rgb(255,255,255); text-indent: 0px; -webkit-text-stroke-width: 0px"><span class="Apple-converted-space"> </span>refers to the entire complement of proteins, including the modifications made to a particular set of proteins, produced by an organism or a cellular system. This will vary with time and distinct requirements, such as stresses, that a cell or organism undergoes. The term<span class="Apple-converted-space"> </span></span><b style="border-top: 0px; border-right: 0px; vertical-align: baseline; white-space: normal; word-spacing: 0px; border-bottom: 0px; text-transform: none; color: rgb(77,77,77); padding-bottom: 0px; text-align: left; padding-top: 0px; font: 900 12px/18px Arial, sans-serif; padding-left: 0px; margin: 0px; border-left: 0px; widows: 1; letter-spacing: normal; padding-right: 0px; background-color: rgb(255,255,255); text-indent: 0px; -webkit-text-stroke-width: 0px; font-stretch: inherit">"proteomics"</b><span style="white-space: normal; word-spacing: 0px; text-transform: none; float: none; color: rgb(77,77,77); text-align: left; font: 12px/18px Arial, sans-serif; widows: 1; display: inline !important; letter-spacing: normal; background-color: rgb(255,255,255); text-indent: 0px; -webkit-text-stroke-width: 0px"><span class="Apple-converted-space"> </span>is a large-scale comprehensive study of a specific proteome, including information on protein abundances, their variations and modifications, along with their interacting partners and networks, in order to understand cellular processes.</span><b style="border-top: 0px; border-right: 0px; vertical-align: baseline; white-space: normal; word-spacing: 0px; border-bottom: 0px; text-transform: none; color: rgb(77,77,77); padding-bottom: 0px; text-align: left; padding-top: 0px; font: 900 12px/18px Arial, sans-serif; padding-left: 0px; margin: 0px; border-left: 0px; widows: 1; letter-spacing: normal; padding-right: 0px; background-color: rgb(255,255,255); text-indent: 0px; -webkit-text-stroke-width: 0px; font-stretch: inherit">“Clinical proteomics”</b><span style="white-space: normal; word-spacing: 0px; text-transform: none; float: none; color: rgb(77,77,77); text-align: left; font: 12px/18px Arial, sans-serif; widows: 1; display: inline !important; letter-spacing: normal; background-color: rgb(255,255,255); text-indent: 0px; -webkit-text-stroke-width: 0px"><span class="Apple-converted-space"> </span>is a sub-discipline of proteomics that involves the application of proteomic technologies on clinical specimens such as blood. Cancer, in particular, is a model disease for applying such technologies to identify unique biosignatures and biomarkers responsible for the diagnosis, prognosis and therapeutic prediction of such disease. Biomarkers are biological molecules found in blood, other body fluids, or tissues that are a sign of a normal or abnormal process, or of a condition or disease. They may also be used to see how well the body responds to a treatment for a disease or condition.</span></p> | <p> <span style="white-space: normal; word-spacing: 0px; text-transform: none; float: none; color: rgb(77,77,77); text-align: left; font: 12px/18px Arial, sans-serif; widows: 1; display: inline !important; letter-spacing: normal; background-color: rgb(255,255,255); text-indent: 0px; -webkit-text-stroke-width: 0px">he term<span class="Apple-converted-space"> </span></span><b style="border-top: 0px; border-right: 0px; vertical-align: baseline; white-space: normal; word-spacing: 0px; border-bottom: 0px; text-transform: none; color: rgb(77,77,77); padding-bottom: 0px; text-align: left; padding-top: 0px; font: 900 12px/18px Arial, sans-serif; padding-left: 0px; margin: 0px; border-left: 0px; widows: 1; letter-spacing: normal; padding-right: 0px; background-color: rgb(255,255,255); text-indent: 0px; -webkit-text-stroke-width: 0px; font-stretch: inherit">"proteome"</b><span style="white-space: normal; word-spacing: 0px; text-transform: none; float: none; color: rgb(77,77,77); text-align: left; font: 12px/18px Arial, sans-serif; widows: 1; display: inline !important; letter-spacing: normal; background-color: rgb(255,255,255); text-indent: 0px; -webkit-text-stroke-width: 0px"><span class="Apple-converted-space"> </span>refers to the entire complement of proteins, including the modifications made to a particular set of proteins, produced by an organism or a cellular system. This will vary with time and distinct requirements, such as stresses, that a cell or organism undergoes. The term<span class="Apple-converted-space"> </span></span><b style="border-top: 0px; border-right: 0px; vertical-align: baseline; white-space: normal; word-spacing: 0px; border-bottom: 0px; text-transform: none; color: rgb(77,77,77); padding-bottom: 0px; text-align: left; padding-top: 0px; font: 900 12px/18px Arial, sans-serif; padding-left: 0px; margin: 0px; border-left: 0px; widows: 1; letter-spacing: normal; padding-right: 0px; background-color: rgb(255,255,255); text-indent: 0px; -webkit-text-stroke-width: 0px; font-stretch: inherit">"proteomics"</b><span style="white-space: normal; word-spacing: 0px; text-transform: none; float: none; color: rgb(77,77,77); text-align: left; font: 12px/18px Arial, sans-serif; widows: 1; display: inline !important; letter-spacing: normal; background-color: rgb(255,255,255); text-indent: 0px; -webkit-text-stroke-width: 0px"><span class="Apple-converted-space"> </span>is a large-scale comprehensive study of a specific proteome, including information on protein abundances, their variations and modifications, along with their interacting partners and networks, in order to understand cellular processes.</span><b style="border-top: 0px; border-right: 0px; vertical-align: baseline; white-space: normal; word-spacing: 0px; border-bottom: 0px; text-transform: none; color: rgb(77,77,77); padding-bottom: 0px; text-align: left; padding-top: 0px; font: 900 12px/18px Arial, sans-serif; padding-left: 0px; margin: 0px; border-left: 0px; widows: 1; letter-spacing: normal; padding-right: 0px; background-color: rgb(255,255,255); text-indent: 0px; -webkit-text-stroke-width: 0px; font-stretch: inherit">“Clinical proteomics”</b><span style="white-space: normal; word-spacing: 0px; text-transform: none; float: none; color: rgb(77,77,77); text-align: left; font: 12px/18px Arial, sans-serif; widows: 1; display: inline !important; letter-spacing: normal; background-color: rgb(255,255,255); text-indent: 0px; -webkit-text-stroke-width: 0px"><span class="Apple-converted-space"> </span>is a sub-discipline of proteomics that involves the application of proteomic technologies on clinical specimens such as blood. Cancer, in particular, is a model disease for applying such technologies to identify unique biosignatures and biomarkers responsible for the diagnosis, prognosis and therapeutic prediction of such disease. Biomarkers are biological molecules found in blood, other body fluids, or tissues that are a sign of a normal or abnormal process, or of a condition or disease. They may also be used to see how well the body responds to a treatment for a disease or condition.</span></p> | ||
<p> </p> | <p> </p> | ||
| − | <h1><span style="font-size: x-large">Proteomics</span></h1> | + | <h1><b><span style="font-size: x-large">Proteomics</span></b></h1> |
<p>Extensive data, generated through crystallography and NMR, are required for proteomic studies. With such data on known proteins, thestructureand itsrelationship to function of newly discovered proteins can beunderstood in a very short time. In such areas,bioinformaticshas an enormousanalytical and predictive potential .<br /> | <p>Extensive data, generated through crystallography and NMR, are required for proteomic studies. With such data on known proteins, thestructureand itsrelationship to function of newly discovered proteins can beunderstood in a very short time. In such areas,bioinformaticshas an enormousanalytical and predictive potential .<br /> | ||
It can help develop better understanding of how proteinsfold and interact with one another and with other biological molecules which in turn will give scientists and doctors better insight into diseases and ways to combat them.</p> | It can help develop better understanding of how proteinsfold and interact with one another and with other biological molecules which in turn will give scientists and doctors better insight into diseases and ways to combat them.</p> | ||
Revision as of 20:54, 11 June 2015
Return to Bioinformatics course 2015 UNIST Students Folder
Return to SaetByeol Kim
Definition
Involves the sequencing of amino acids in a protein, determining its three dimensional structure and relating it to the function of the protein.
he term "proteome" refers to the entire complement of proteins, including the modifications made to a particular set of proteins, produced by an organism or a cellular system. This will vary with time and distinct requirements, such as stresses, that a cell or organism undergoes. The term "proteomics" is a large-scale comprehensive study of a specific proteome, including information on protein abundances, their variations and modifications, along with their interacting partners and networks, in order to understand cellular processes.“Clinical proteomics” is a sub-discipline of proteomics that involves the application of proteomic technologies on clinical specimens such as blood. Cancer, in particular, is a model disease for applying such technologies to identify unique biosignatures and biomarkers responsible for the diagnosis, prognosis and therapeutic prediction of such disease. Biomarkers are biological molecules found in blood, other body fluids, or tissues that are a sign of a normal or abnormal process, or of a condition or disease. They may also be used to see how well the body responds to a treatment for a disease or condition.
Proteomics
Extensive data, generated through crystallography and NMR, are required for proteomic studies. With such data on known proteins, thestructureand itsrelationship to function of newly discovered proteins can beunderstood in a very short time. In such areas,bioinformaticshas an enormousanalytical and predictive potential .
It can help develop better understanding of how proteinsfold and interact with one another and with other biological molecules which in turn will give scientists and doctors better insight into diseases and ways to combat them.
Proteomics Approach
