Difference between revisions of "BRCA1"
imported>Youyoung Kim |
imported>Youyoung Kim |
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Line 149: | Line 149: | ||
<p><a href="http://www.compbio.dundee.ac.uk/jpred4/results/jp_U3PpvGT/jp_U3PpvGT.simple.html">http://www.compbio.dundee.ac.uk/jpred4/results/jp_U3PpvGT/jp_U3PpvGT.simple.html</a></p> | <p><a href="http://www.compbio.dundee.ac.uk/jpred4/results/jp_U3PpvGT/jp_U3PpvGT.simple.html">http://www.compbio.dundee.ac.uk/jpred4/results/jp_U3PpvGT/jp_U3PpvGT.simple.html</a></p> | ||
− | <p> | + | <p><a href="http://www.compbio.dundee.ac.uk/jpred4/results/jp_cbRrRrH/jp_cbRrRrH.simple.html">http://www.compbio.dundee.ac.uk/jpred4/results/jp_cbRrRrH/jp_cbRrRrH.simple.html</a></p> |
− | < | + | <h2 style="font-style: italic"><big><span style="font-size:14px">H: Alpha helix, E: Beta sheet</span></big><br /> |
− | <code>-----HHHHHHHHHHHHHHHH-------HH------------HHHHHHHHHHHH-----------------------HHHHHHHHHHHHHHHH----------------------HHH--</code></ | + | <span style="font-size:11px"><code>-----HHHHHHHHHHHHHHHH-------HH------------HHHHHHHHHHHH-----------------------HHHHHHHHHHHHHHHH----------------------HHH--</code></span></h2> |
− | < | + | <h2 style="font-style: italic"><span style="font-size:11px"><code>--EEEE------HHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHH----EEEEEE----HHHHHHHHHHHHHHHHH-----HHHHHHHHHH-HHHHHH---------------</code></span></h2> |
− | < | + | <h2 style="font-style: italic"><span style="font-size:11px"><code>-------HHHHHHHH----------------------------------EEE----------------------------------------------EEE-------------------</code></span></h2> |
− | < | + | <h2 style="font-style: italic"><span style="font-size:11px"><code>-----------HHHHHHHHHHHHHHHH---------------------------------------------------EEEE----------------EEEEEEEE--------------</code></span></h2> |
− | < | + | <h2 style="font-style: italic"><span style="font-size:11px"><code>----------------------------------------EEEEE-------------------EEEE----------------------------------------------------</code></span></h2> |
− | < | + | <h2 style="font-style: italic"><span style="font-size:11px"><code>----------------------EEE-----------------------------------------------------------------------------------------------</code></span></h2> |
− | < | + | <h2 style="font-style: italic"><span style="font-size:11px"><code>--------------EEE----------HHHHH----------------EEEE----</code>------EEEE------------------EEEE--------------------------------HHH----------HHHHHHHHHH--</span></h2> |
− | < | + | <h2 style="font-style: italic"><span style="font-size:11px">----------------EEE--------------------HHHHH----------------------------------EEEEE-----------------E---------------------EEEEE--------------------EE---------------------------------</span></h2> |
− | < | + | <h2 style="font-style: italic"><span style="font-size:11px">-----------EEEE------EEE-------EE---------------------------EE------EEEE-----------------------------------------------------EEEEE------E-----------------------------------------HHH</span></h2> |
− | < | + | <h2 style="font-style: italic"><span style="font-size:11px">HHH----------------EEEE----------------------------------------------------HH-----------<code>---------------------------------------------------EEE--------</code></span></h2> |
+ | |||
+ | <h2 style="font-style: italic"><span style="font-size:11px"><code>--------------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------------------------EEE-----------------------------------------</code></span></h2> | ||
+ | |||
+ | <h2 style="font-style: italic"><span style="font-size:11px"><code>------------------------------------------------------------------------------------------------------------------------</code></span></h2> | ||
+ | |||
+ | <h2 style="font-style: italic"><span style="font-size:11px"><code>------------------------------EEEEEEE----HHHHHHHHHHHH---EEE--------EEEEE------EHHHHHHHHHHH-------HHHHHHHHHH---------E---</code></span></h2> | ||
+ | |||
+ | <h2 style="font-style: italic"><code><span style="font-size:11px">----------HHHHHHH---------EEEEEE------HHHHHHHHHH---EEE-------------EEEEEE-----HHHHHHHHHH-----EE-HHHHHHHHHH-------------------</span></code><br /> | ||
+ | </h2> | ||
<p> </p> | <p> </p> |
Latest revision as of 15:13, 13 June 2016
<DNA>
ATGGATTTATCTGCTCTTCGCGTTGAAGAAGTACAAAATGTCATTAATGCTATGCAGAAAATCTTAGAGTGTCCCATCTGTCTGGAGTTGATCAAGGAACCTGTCTCCACAA
AGTGTGACCACATATTTTGCAAATTTTGCATGCTGAAACTTCTCAACCAGAAGAAAGGGCCTTCACAGTGTCCTTTATGTAAGAATGATATAACCAAAAGGAGCCTACAAG
AAAGTACGAGATTTAGTCAACTTGTTGAAGAGCTATTGAAAATCATTTGTGCTTTTCAGCTTGACACAGGTTTGGAGTATGCAAACAGCTATAATTTTGCAAAAAAGGAAA
ATAACTCTCCTGAACATCTAAAAGATGAAGTTTCTATCATCCAAAGTATGGGCTACAGAAACCGTGCCAAAAGACTTCTACAGAGTGAACCCGAAAATCCTTCCTTGCAGG
AAACCAGTCTCAGTGTCCAACTCTCTAACCTTGGAACTGTGAGAACTCTGAGGACAAAGCAGCGGATACAACCTCAAAAGACGTCTGTCTACATTGAATTGGGATCTGAT
TCTTCTGAAGATACCGTTAATAAGGCAACTTATTGCAGTGTGGGAGATCAAGAATTGTTACAAATCACCCCTCAAGGAACCAGGGATGAAATCAGTTTGGATTCTGCAAAAA
AGGCTGCTTGTGAATTTTCTGAGACGGATGTAACAAATACTGAACATCATCAACCCAGTAATAATGATTTGAACACCACTGAGAAGCGTGCAGCTGAGAGGCATCCAGAA
AAGTATCAGGGTAGTTCTGTTTCAAACTTGCATGTGGAGCCATGTGGCACAAATACTCATGCCAGCTCATTACAGCATGAGAACAGCAGTTTATTACTCACTAAAGACAGAA
TGAATGTAGAAAAGGCTGAATTCTGTAATAAAAGCAAACAGCCTGGCTTAGCAAGGAGCCAACATAACAGATGGGCTGGAAGTAAGGAAACATGTAATGATAGGCGGAC
TCCCAGCACAGAAAAAAAGGTAGATCTGAATGCTGATCCCCTGTGTGAGAGAAAAGAATGGAATAAGCAGAAACTGCCATGCTCAGAGAATCCTAGAGATACTGAAGATG
TTCCTTGGATAACACTAAATAGCAGCATTCAGAAAGTTAATGAGTGGTTTTCCAGAAGTGATGAACTGTTAGGTTCTGATGACTCACATGATGGGGAGTCTGAATCAAATGC
CAAAGTAGCTGATGTATTGGACGTTCTAAATGAGGTAGATGAATATTCTGGTTCTTCAGAGAAAATAGACTTACTGGCCAGTGATCCTCATGAGGCTTTAATATGTAAAAGTG
AAAGAGTTCACTCCAAATCAGTAGAGAGTAATATTGAAGACAAAATATTTGGGAAAACCTATCGGAAGAAGGCAAGCCTCCCCAACTTAAGCCATGTAACTGAAAATCTAA
TTATAGGAGCATTTGTTACTGAGCCACAGATAATACAAGAGCGTCCCCTCACAAATAAATTAAAGCGTAAAAGGAGACCTACATCAGGCCTTCATCCTGAGGATTTTATCAA
GAAAGCAGATTTGGCAGTTCAAAAGACTCCTGAAATGATAAATCAGGGAACTAACCAAACGGAGCAGAATGGTCAAGTGATGAATATTACTAATAGTGGTCATGAGAATAA
AACAAAAGGTGATTCTATTCAGAATGAGAAAAATCCTAACCCAATAGAATCACTCGAAAAAGAATCTGCTTTCAAAACGAAAGCTGAACCTATAAGCAGCAGTATAAGCAAT
ATGGAACTCGAATTAAATATCCACAATTCAAAAGCACCTAAAAAGAATAGGCTGAGGAGGAAGTCTTCTACCAGGCATATTCATGCGCTTGAACTAGTAGTCAGTAGAAATC
TAAGCCCACCTAATTGTACTGAATTGCAAATTGATAGTTGTTCTAGCAGTGAAGAGATAAAGAAAAAAAAGTACAACCAAATGCCAGTCAGGCACAGCAGAAACCTACAAC
TCATGGAAGGTAAAGAACCTGCAACTGGAGCCAAGAAGAGTAACAAGCCAAATGAACAGACAAGTAAAAGACATGACAGCGATACTTTCCCAGAGCTGAAGTTAACAAA
TGCACCTGGTTCTTTTACTAAGTGTTCAAATACCAGTGAACTTAAAGAATTTGTCAATCCTAGCCTTCCAAGAGAAGAAAAAGAAGAGAAACTAGAAACAGTTAAAGTGTCTA
ATAATGCTGAAGACCCCAAAGATCTCATGTTAAGTGGAGAAAGGGTTTTGCAAACTGAAAGATCTGTAGAGAGTAGCAGTATTTCATTGGTACCTGGTACTGATTATGGCAC
TCAGGAAAGTATCTCGTTACTGGAAGTTAGCACTCTAGGGAAGGCAAAAACAGAACCAAATAAATGTGTGAGTCAGTGTGCAGCATTTGAAAACCCCAAGGGACTAATTCA
TGGTTGTTCCAAAGATAATAGAAATGACACAGAAGGCTTTAAGTATCCATTGGGACATGAAGTTAACCACAGTCGGGAAACAAGCATAGAAATGGAAGAAAGTGAACTTGA
TGCTCAGTATTTGCAGAATACATTCAAGGTTTCAAAGCGCCAGTCATTTGCTCCGTTTTCAAATCCAGGAAATGCAGAAGAGGAATGTGCAACATTCTCTGCCCACTCTGGGT
CCTTAAAGAAACAAAGTCCAAAAGTCACTTTTGAATGTGAACAAAAGGAAGAAAATCAAGGAAAGAATGAGTCTAATATCAAGCCTGTACAGACAGTTAATATCACTGCAG
GCTTTCCTGTGGTTGGTCAGAAAGATAAGCCAGTTGATAATGCCAAATGTAGTATCAAAGGAGGCTCTAGGTTTTGTCTATCATCTCAGTTCAGAGGCAACGAAACTGGACT
CATTACTCCAAATAAACATGGACTTTTACAAAACCCATATCGTATACCACCACTTTTTCCCATCAAGTCATTTGTTAAAACTAAATGTAAGAAAAATCTGCTAGAGGAAAACTTT
GAGGAACATTCAATGTCACCTGAAAGAGAAATGGGAAATGAGAACATTCCAAGTACAGTGAGCACAATTAGCCGTAATAACATTAGAGAAAATGTTTTTAAAGAAGCCAGC
TCAAGCAATATTAATGAAGTAGGTTCCAGTACTAATGAAGTGGGCTCCAGTATTAATGAAATAGGTTCCAGTGATGAAAACATTCAAGCAGAACTAGGTAGAAACAGAGGGC
CAAAATTGAATGCTATGCTTAGATTAGGGGTTTTGCAACCTGAGGTCTATAAACAAAGTCTTCCTGGAAGTAATTGTAAGCATCCTGAAATAAAAAAGCAAGAATATGAAGAA
GTAGTTCAGACTGTTAATACAGATTTCTCTCCATATCTGATTTCAGATAACTTAGAACAGCCTATGGGAAGTAGTCATGCATCTCAGGTTTGTTCTGAGACACCTGATGACCTGT
TAGATGATGGTGAAATAAAGGAAGATACTAGTTTTGCTGAAAATGACATTAAGGAAAGTTCTGCTGTTTTTAGCAAAAGCGTCCAGAAAGGAGAGCTTAGCAGGAGTCCTAG
CCCTTTCACCCATACACATTTGGCTCAGGGTTACCGAAGAGGGGCCAAGAAATTAGAGTCCTCAGAAGAGAACTTATCTAGTGAGGATGAAGAGCTTCCCTGCTTCCAACAC
TTGTTATTTGGTAAAGTAAACAATATACCTTCTCAGTCTACTAGGCATAGCACCGTTGCTACCGAGTGTCTGTCTAAGAACACAGAGGAGAATTTATTATCATTGAAGAATAGCT
TAAATGACTGCAGTAACCAGGTAATATTGGCAAAGGCATCTCAGGAACATCACCTTAGTGAGGAAACAAAATGTTCTGCTAGCTTGTTTTCTTCACAGTGCAGTGAATTGGAA
GACTTGACTGCAAATACAAACACCCAGGATCCTTTCTTGATTGGTTCTTCCAAACAAATGAGGCATCAGTCTGAAAGCCAGGGAGTTGGTCTGAGTGACAAGGAATTGGTTTC
AGATGATGAAGAAAGAGGAACGGGCTTGGAAGAAAATAATCAAGAAGAGCAAAGCATGGATTCAAACTTAGGTGAAGCAGCATCTGGGTGTGAGAGTGAAACAAGCGTCT
CTGAAGACTGCTCAGGGCTATCCTCTCAGAGTGACATTTTAACCACTCAGCAGAGGGATACCATGCAACATAACCTGATAAAGCTCCAGCAGGAAATGGCTGAACTAGAAG
CTGTGTTAGAACAGCATGGGAGCCAGCCTTCTAACAGCTACCCTTCCATCATAAGTGACTCTTCTGCCCTTGAGGACCTGCGAAATCCAGAACAAAGCACATCAGAAAAAGC
AGTATTAACTTCACAGAAAAGTAGTGAATACCCTATAAGCCAGAATCCAGAAGGCCTTTCTGCTGACAAGTTTGAGGTGTCTGCAGATAGTTCTACCAGTAAAAATAAAGAAC
CAGGAGTGGAAAGGTCATCCCCTTCTAAATGCCCATCATTAGATGATAGGTGGTACATGCACAGTTGCTCTGGGAGTCTTCAGAATAGAAACTACCCATCTCAAGAGGAGCT
CATTAAGGTTGTTGATGTGGAGGAGCAACAGCTGGAAGAGTCTGGGCCACACGATTTGACGGAAACATCTTACTTGCCAAGGCAAGATCTAGAGGGAACCCCTTACCTGGAA
TCTGGAATCAGCCTCTTCTCTGATGACCCTGAATCTGATCCTTCTGAAGACAGAGCCCCAGAGTCAGCTCGTGTTGGCAACATACCATCTTCAACCTCTGCATTGAAAGTTCCCC
AATTGAAAGTTGCAGAATCTGCCCAGAGTCCAGCTGCTGCTCATACTACTGATACTGCTGGGTATAATGCAATGGAAGAAAGTGTGAGCAGGGAGAAGCCAGAATTGACAGC
TTCAACAGAAAGGGTCAACAAAAGAATGTCCATGGTGGTGTCTGGCCTGACCCCAGAAGAATTTATGCTCGTGTACAAGTTTGCCAGAAAACACCACATCACTTTAACTAATCT
AATTACTGAAGAGACTACTCATGTTGTTATGAAAACAGATGCTGAGTTTGTGTGTGAACGGACACTGAAATATTTTCTAGGAATTGCGGGAGGAAAATGGGTAGTTAGCTATTTC
TGGGTGACCCAGTCTATTAAAGAAAGAAAAATGCTGAATGAGCATGATTTTGAAGTCAGAGGAGATGTGGTCAATGGAAGAAACCACCAAGGTCCAAAGCGAGCAAGAGAAT
CCCAGGACAGAAAGATCTTCAGGGGGCTAGAAATCTGTTGCTATGGGCCCTTCACCAACATGCCCACAGATCAACTGGAATGGATGGTACAGCTGTGTGGTGCTTCTGTGGTG
AAGGAGCTTTCATCATTCACCCTTGGCACAGGTGTCCACCCAATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGCTTCCATGCAATTGGGCAGATGTGTGAGGC
ACCTGTGGTGACCCGAGAGTGGGTGTTGGACAGTGTAGCACTCTACCAGTGCCAGGAGCTGGACACCTACCTGATACCCCAGATCCCCCACAGCCACTACTGA
<Protein>
MDLSALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNFAKKENNSPEHLKD
EVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRTKQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACEFSETDVTNTEHH
QPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHENSSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTPSTEKKVDLNADPLCERKE
WNKQKLPCSENPRDTEDVPWITLNSSIQKVNEWFSRSDELLGSDDSHDGESESNAKVADVLDVLNEVDEYSGSSEKIDLLASDPHEALICKSERVHSKSVESNIEDKIFGKTYRKKAS
LPNLSHVTENLIIGAFVTEPQIIQERPLTNKLKRKRRPTSGLHPEDFIKKADLAVQKTPEMINQGTNQTEQNGQVMNITNSGHENKTKGDSIQNEKNPNPIESLEKESAFKTKAEPISS
SISNMELELNIHNSKAPKKNRLRRKSSTRHIHALELVVSRNLSPPNCTELQIDSCSSSEEIKKKKYNQMPVRHSRNLQLMEGKEPATGAKKSNKPNEQTSKRHDSDTFPELKLTNAP
GSFTKCSNTSELKEFVNPSLPREEKEEKLETVKVSNNAEDPKDLMLSGERVLQTERSVESSSISLVPGTDYGTQESISLLEVSTLGKAKTEPNKCVSQCAAFENPKGLIHGCSKDNRND
TEGFKYPLGHEVNHSRETSIEMEESELDAQYLQNTFKVSKRQSFAPFSNPGNAEEECATFSAHSGSLKKQSPKVTFECEQKEENQGKNESNIKPVQTVNITAGFPVVGQKDKPVDNA
KCSIKGGSRFCLSSQFRGNETGLITPNKHGLLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHSMSPEREMGNENIPSTVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEIGS
SDENIQAELGRNRGPKLNAMLRLGVLQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPYLISDNLEQPMGSSHASQVCSETPDDLLDDGEIKEDTSFAENDIKESSAVFSKS
VQKGELSRSPSPFTHTHLAQGYRRGAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQSTRHSTVATECLSKNTEENLLSLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQ
CSELEDLTANTNTQDPFLIGSSKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGEAASGCESETSVSEDCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAE
LEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKV
VDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKR
MSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLE
ICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIPQIPHSHY*
<Structure>
http://www.compbio.dundee.ac.uk/jpred4/results/jp_pOWsY7j/jp_pOWsY7j.simple.html
http://www.compbio.dundee.ac.uk/jpred4/results/jp_U3PpvGT/jp_U3PpvGT.simple.html
http://www.compbio.dundee.ac.uk/jpred4/results/jp_cbRrRrH/jp_cbRrRrH.simple.html
Contents
- 1 H: Alpha helix, E: Beta sheet -----HHHHHHHHHHHHHHHH-------HH------------HHHHHHHHHHHH-----------------------HHHHHHHHHHHHHHHH----------------------HHH--
- 2 --EEEE------HHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHH----EEEEEE----HHHHHHHHHHHHHHHHH-----HHHHHHHHHH-HHHHHH---------------
- 3 -------HHHHHHHH----------------------------------EEE----------------------------------------------EEE-------------------
- 4 -----------HHHHHHHHHHHHHHHH---------------------------------------------------EEEE----------------EEEEEEEE--------------
- 5 ----------------------------------------EEEEE-------------------EEEE----------------------------------------------------
- 6 ----------------------EEE-----------------------------------------------------------------------------------------------
- 7 --------------EEE----------HHHHH----------------EEEE----------EEEE------------------EEEE--------------------------------HHH----------HHHHHHHHHH--
- 8 ----------------EEE--------------------HHHHH----------------------------------EEEEE-----------------E---------------------EEEEE--------------------EE---------------------------------
- 9 -----------EEEE------EEE-------EE---------------------------EE------EEEE-----------------------------------------------------EEEEE------E-----------------------------------------HHH
- 10 HHH----------------EEEE----------------------------------------------------HH--------------------------------------------------------------EEE--------
- 11 --------------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------------------------EEE-----------------------------------------
- 12 ------------------------------------------------------------------------------------------------------------------------
- 13 ------------------------------EEEEEEE----HHHHHHHHHHHH---EEE--------EEEEE------EHHHHHHHHHHH-------HHHHHHHHHH---------E---
- 14 ----------HHHHHHH---------EEEEEE------HHHHHHHHHH---EEE-------------EEEEEE-----HHHHHHHHHH-----EE-HHHHHHHHHH-------------------
H: Alpha helix, E: Beta sheet
-----HHHHHHHHHHHHHHHH-------HH------------HHHHHHHHHHHH-----------------------HHHHHHHHHHHHHHHH----------------------HHH--
--EEEE------HHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHH----EEEEEE----HHHHHHHHHHHHHHHHH-----HHHHHHHHHH-HHHHHH---------------
-------HHHHHHHH----------------------------------EEE----------------------------------------------EEE-------------------
-----------HHHHHHHHHHHHHHHH---------------------------------------------------EEEE----------------EEEEEEEE--------------
----------------------------------------EEEEE-------------------EEEE----------------------------------------------------
----------------------EEE-----------------------------------------------------------------------------------------------
--------------EEE----------HHHHH----------------EEEE----
------EEEE------------------EEEE--------------------------------HHH----------HHHHHHHHHH--
----------------EEE--------------------HHHHH----------------------------------EEEEE-----------------E---------------------EEEEE--------------------EE---------------------------------
-----------EEEE------EEE-------EE---------------------------EE------EEEE-----------------------------------------------------EEEEE------E-----------------------------------------HHH
HHH----------------EEEE----------------------------------------------------HH--------------------------------------------------------------EEE--------
--------------HHHHHHHHHHHHHHHHHHHHHHHHHHHH----------------------------------EEE-----------------------------------------
------------------------------------------------------------------------------------------------------------------------
------------------------------EEEEEEE----HHHHHHHHHHHH---EEE--------EEEEE------EHHHHHHHHHHH-------HHHHHHHHHH---------E---
----------HHHHHHH---------EEEEEE------HHHHHHHHHH---EEE-------------EEEEEE-----HHHHHHHHHH-----EE-HHHHHHHHHH-------------------