Difference between revisions of "KSH 0610 Epigenomics"
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Revision as of 16:47, 10 June 2016
Epigenomics - Epi(Outside) + Genomics(The study of genome, especially function and structure analysis)
- The study of the complete set of epigenetic modifications on the genetic material of a cell
- Epigenetic modification
- DNA methylation by DNMT (DNA methyltransferase)
- Histone modification - acetylation, methylation, phosphorylation and so on
- Epigenetic modifications play an important role in gene expression and regulation
Ex) It could affect Tumorigenesis
Ex) DNA imprinting
- The effects of chromatin structure on the function of the included genes
- Chromatin structure
- Euchromatin - a lightly packed form of chromatin. It is often under active transcription state.
- Heterochromatin - a tightly packed form of chromatin - inaccessible to polymerase and not transcribed
- Nucleosome - a basic unit of DNA packing in eukaryotes, consisting of 8 histone proteins and a segment of DNA (around 147bp)
