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<p><strong>Epigenomics & Proteomics</strong></p>
<p>Epi(outside)</p>
<p>Reversible DNA and Histone modification and RNA interference -> causing chage of gene expression</p>
<p>FXS도 관련있음histone acetylation/methylation</p> <p>Diseases related to the histone modification </p> <p>How do we study?</p>
<p>histone acetylation1. Bisulfite sequencing : treat cytosine with bisulfite changing it to be uracil ! but leaves methylcytosine unaffected. see with cytosine is changed by sequencing the DNA before and after the bisulfite treatment</methylationp> <p>2. Nonmethylated specific PCR</p> <p><strong>Proteomic</strong></p> <p>Phosphorylation is the switch of proteins. and it requires energy </p> <p>Proteins - a helix + b sheet for stable structure + coils to bind others</p> <p>Coils are to bind and to attack.</p> <p>Glycosylation</p> <p>Sulfation</p> <p>How?</p> <p>1. 2D SDS PAGE</p>
<p> 2. Mass spectrometer</p>
<p> </p>
