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<h3>Can miRNA be available for a therapy about an intractable disease associated with a gene?</h3>
<p> </p> <h4>Abstract</h4> <p>Many disease is related with gene that express the some protein. And MicroRNA(miRNA) is a kind of regulatory gene. It can repress the gene expression. Recently gene therapy is developed. If so miRNA can be one of the treatments about an intractable disease associated with a gene.</p> <h4>abstractIntroduction</h4> <p>Gene is the most central element to produce proteins in the body. Gene control how cell work by making proteins that have specific functions and act as messengers for the cell. Therefore, each gene must not have some errors. This is so the protein can perform the correct function for the cell. But many disease is caused by the gene that makes the some proteins. For example, cancer begins when one or more genes in a cell are mutated, or changed. This creates an abnormal protein or no protein at all. An abnormal protein provides different information than a normal protein, which can cause cells to multiply uncontrollably and become cancerous. Thus, our bodies are determined in the expression of genes. However, there is also a mechanism in the body that prevents the expression of the gene. MicroRNA(miRNA) is a kind of regulatory gene, that functions in RNA silencing and post-transcriptional regulation of gene expression. their characteristic structure helps identify them and predict the target genes they might regulate. If so miRNA can be one of the treatments about an intractable disease associated with a gene. Because miRNA can be specified target gene and interfere the translation of proteins by ribosome.</p> <h4>Actually miRNA is related with the cancer.</h4> <p>When we look at the relationship between Mirna and cancer, they actually have quite a lot of relationships. MiRNA are generally downregulated in cancer. Some people already have GENE, which causes CANCER, and many miRNAs are involved and blocking its expression. This was demonstrated in a MOUSE MODEL experiment. Over the past decade, the degree to which miRNAs are involved in cancer has really become apparent. As has the sheer diversity of mechanisms by which miRNA function is deregulated, the major general causes of altered miRNA expression in cancer are discussed below and summarised in Figure.</p>
<p> If so, can these mutated miRNAs be treated and replaced?</p>
<ph4>Gene is the most central element to produce proteins in the body, and everything in human is determined by Cancer gene. and disease like a cancer therapy is associated with the gene. If so i thought 'Can miRNA be available for a therapy about an intractable disease associated with a gene?'. Because miRNA can be specified target gene and interfere the translation of proteins by ribosomealready underway.</ph4>
<p>So answer is 'YES. miRNA can be available for a therapy'. Already many scientists Many researchers are studying about these problem and the relationship between nature of cancer and genes, and miRNA-based therapies are under development. Although it is still a trial and error step, and there are many difficulties, it is expected that perfect miRNA has been foundTREATMENTS will be developed if precise cause of GENE and CANCER is identified.</p>
<ph4>but limitation and difficulties also exist. Conclusion</ph4>
<p>first,MiRNA can be one of the treatments about Low permeation an intractable disease like the cancer. Already many scientists study the source of cancer and miRNA by physical and physiological barriers of cancer tissue. Because abnormal vascular structure of tumorAlthough the gene therapy is not perfect, it has a potential as a treatment.</p>
<p>second, Unintended effects of miRNA. Because miRNAs target different pathways, unwanted gene suppression of cancer-suppressing genes may occur. This unintended effect may cause potential toxicity or reduce the effectiveness of the treatment.</p>
<h3>related paper</h3>
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<td style="width:50%">http://www.ibric.org/myboard/read.php?Board=report&id=2489</td>
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<td><a href="https://www.sciencedirect.com/science/article/pii/S1574789112000981">MicroRNA and cancer</a><br />
Martin D. Jansson, Anders H. Lund*<br />
Biotech Research and Innovation Centre and Centre for Epigenetics, University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen,<br />
Denmark</td>
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<td>https://www.cancer.net/navigating-cancer-care/cancer-basics/genetics/genetics-cancer</td>
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<td>http://www.kosen21.org/info/kosenReport/reportView.do?articleSeq=759471</td>
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<td>https://www.nature.com/cgt/about/</td>
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