View source for Links between Neuroscience and Genomics

<p>My question is - is it effective/ inspiring/efficient/rational/relevant to study nervous system and problems associated with it by using genomics techniques ()&nbsp;</p>

<p>I will argue here that</p>

<p>I believe that&nbsp;</p>

<p>I will ...&nbsp;</p>

<p>&nbsp;</p>

<p>&quot;An additional, sometimes unspoken, impediment to the more widespread adoption of &lsquo;- omics&rsquo; fields (&lsquo;omics&rsquo;) in neuroscience research is an underlying tension between the hypothesis-testing approach applied in the typical neurobiology laboratory</p>

<p>and the discovery-based disciplines of genetics, genomics, and proteomics (Box 1).&quot;</p>

<p>The omics view is that an understanding of the organization and structure of the genome and the high-throughput measurements of the relationships of its elements, or gene products, provides a systematic basis on which t</p>

<p>understand biological processes.Furthermore, significant value is placed on resource building and data sharing.</p>

<p>These approaches, which provide a new framework for the rapidly growing fields of neurogenetics, neurogenomics and systems biology, and the challenges that accompany them, are the subject of this Review.</p>

<p>We discuss the value of data sharing and provide some key examples of neuroinformatics-based or omics-based resources, highlighting areas in which genetic and functional genomic approaches have brought new biological insight to different areas of neuroscience.</p>

<p>We conclude with a discussion of the new frontiers in biological networks and systems biology.</p>

<p>&nbsp;</p>

<p>&nbsp;</p>

<p>&nbsp;</p>

<p>&nbsp;</p>

<p>&nbsp;</p>

<p>1. Structure:&nbsp;<strong>essays should make an argument:&nbsp;</strong>your essay should have a point and reach a conclusion, even if tentative, and you should try to convince the reader that your point is correct.</p>

<p>This is the most important single point in writing a good essay. It will help you make it well organized, and well-written. Clarity of thought and argument provide the necessary basis for a clear writing style.&nbsp;</p>

<p>2. It is key to back up each crucial point that you make with data. Don&#39;t just cite the study, but briefly, describe its key result(s) in a sentence or two, and explain, explicitly, why this supports your point</p>

<p>Any statements of nonobvious fact (e.g. &quot;monkeys can follow gaze&quot;, or &quot;dopamine is necessary for motor function&quot;) should be followed by a reference (even if only to a textbook).</p>

<p>3. Proof: Note that the logic of scientific discovery is that of generating a list of possibilities (postulating hypotheses) and then doing experiments to test them. We proceed by rejecting false hypotheses, rather than proving true ones.</p>

<p>&nbsp;</p>

<p>&nbsp;</p>

<p>&nbsp;</p>

<p><strong>(What counts as a good argument, or a solid conclusion? There is room for considerable creativity here, depending on the topic. It is easier to say what does not count as a good conclusion.</strong></p>

<p><strong>For example, you should never just review a study or studies, and conclude that &quot;more work is necessary&quot;.</strong></p>

<p><strong>More work is always necessary, and YOUR work in this essay is to reach a more substantive conclusion than that.</strong></p>

<p><strong>A recapitulation of some experiments with no substantive conclusions does not constitute a good essay, however accurate.)</strong></p>

<p>[[a]]</p>

<p>&nbsp;</p>

<p>&nbsp;</p>