View source for Lecture 3 - Genomics

<p>What is genomics?</p>

<p>Genomics -&gt; Bioinformatics</p>

<p>&nbsp;</p>

<p>&lt;T - graph&gt;</p>

<p>[[File:T-graph_YK.png|300px|thumb|alt text]]</p>

<p>Diverse : Type/Species/People - ex) normal cell vs cancer cell&nbsp;(Horizontal axis in T-graph)</p>

<p>Variability : Gradient of the type&nbsp;(Verticall axis in T-graph)</p>

<p>&nbsp;</p>

<p>&lt;Genome + Envirome =&gt; Phenome&gt;</p>

<p>[[File:Geno+Enviro = Pheno.png|300px|thumb|alt text]]</p>

<p>Genome : genetic factor (Korean genome, neurodegenerative genome)</p>

<p>Envirome : environmental factor (Korean enviornment, boxing)</p>

<p>&nbsp;</p>

<p>Phenome : Outcome of the&nbsp;genetic factor and&nbsp;environmental factor (neurodegenerative genome + boxing = parkinson)</p>

<p>&nbsp;</p>

<p>In real world, there are complicated&nbsp;factor about&nbsp;phenome -&gt; It is difficult to predict</p>

<p>-&gt; Solution: 1. Exact data 2. principle 3. big computer</p>

<p>&nbsp;</p>

<p>Sequencing: 1st(ex: sanger) 2nd(ex: shotgun) 3rd(single molecule) 4th(ex: nanopore)</p>

<p>Reference genome: criteria overlapping depth&nbsp;for mapping</p>

<p>&nbsp;</p>

<p>Genome analysis</p>

<p>1. Select sample or species</p>

<p>2. design</p>

<p>3. experiment</p>

<p>ex) Tiger/Whale</p>

<p>1. Tiger is symbolic(cat/lion/tiger) and carnivore / Whale is evolutionally interesting, live very long(average 200 years)</p>

<p>2. design how to..</p>

<p>3. compare the color of fur(white vs orange)</p>

<p>&nbsp;</p>

<p>De Novo(the new) - the first genome not using reference genome&nbsp;</p>

<p>&nbsp;</p>

<p>Glutathion is the antioxidant to reduce the ROS(reactive oxygen species)</p>

<p>Question : Is there any supplements or drugs to increase the level of glutathion? - coffee, green tea, wine....</p>

<p>&nbsp;</p>

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<p>[[Class_talking_%26_question]]</p>