View source for Canceromics and Geromics by MJ 20180608

<p>-Question: How can we measure length of telomere?</p>

<p>using FISH, it is accurate and by using light intensity, we can measure.</p>

<p>My question: Can we get absolute value for length?</p>

<p>We have control to compare, so it may measure absolutely.</p>

<p>&nbsp;</p>

<p>-Because it is difficult to target cancer gene and cancer is multi-step disease.</p>

<p>Therefore, it is difficult to cure cancer.</p>

<p>But by using single cell sequencing, we can find potential drug for cancer</p>

<p>&nbsp;</p>

<p>-How many nucleotides are shortened in each cell division?</p>

<p>Original telomere length: 15,000 nt</p>

<p>Remaining telomere length after cell division: 5,000 nt</p>

<p>Telomere length shortened by cell division: 10,000 nt</p>

<p>Therefore, 10,000 nt / 50~70 (usual division of somatic cells) = 150~200 nt</p>

<p>&nbsp;</p>

<p>-Mouse has 5 times longer telomere length than human, but mouse dies faster than human. Why?</p>

<p>&nbsp;Do they lose telomere faster?</p>

<p>&nbsp;Mouse have many offspring and short lifespan.</p>

<p>&nbsp;Human have lots of repair system, but mice not.</p>

<p>&nbsp;</p>

<p>-Is aging a disease?</p>

<p>Yes, I think it is a disease.</p>

<p>&nbsp;</p>

<p>-Darwin vs Lamark</p>

<p>&nbsp;</p>

<p>-Old vs young genome</p>

<p>&nbsp;</p>

<p>[[Lecture &amp; Self-study by MJ 20180427]]</p>