View source for Canceromics and Geromics Class, 180608

<p><strong>Presentation about &lsquo;Canceromics and Geromics&rsquo;</strong></p>

<p>-What is Canceromics?</p>

<p>&nbsp;</p>

<p>-Why is it so difficult to cure cancer?</p>

<p style="margin-left: 40px">Cancer is a multi-step disease.</p>

<p style="margin-left: 40px">Cancers are clonal and heterogenic, so it is not easy to target one gene.</p>

<p>&nbsp;</p>

<p>-How can we find potential drug targets for cancer?</p>

<p style="margin-left: 40px">Single cell sequencing</p>

<p style="margin-left: 40px">Application : Precision medicine</p>

<p>&nbsp;</p>

<p>-What is Geromics?</p>

<p>&nbsp;</p>

<p>-Introduction of Geromics Inc.</p>

<p style="margin-left: 40px">Geromics technologies</p>

<p style="margin-left: 40px">Business scope : Personal Genomics, Telomere</p>

<p style="margin-left: 40px">&nbsp;</p>

<p>-What is telomere and telomerase?</p>

<p>&nbsp;</p>

<p>-<strong>How can we measure telomere length?</strong></p>

<p style="margin-left: 40px">FISH(fluorescent in situ hybridization) &ndash; measured by light intensity, precise method for measurement, expensive</p>

<p style="margin-left: 40px">*in situ : &lsquo;on site&rsquo; or &lsquo;in position&rsquo;</p>

<p style="margin-left: 40px">&nbsp;</p>

<p><strong>-How many nucleotides are shortened in each cell division?</strong></p>

<p>My answer is</p>

<p style="margin-left: 40px">Original telomere length : 15,000 nucleotides</p>

<p style="margin-left: 200px">(6 nucleotides are repeated approximately 2,500 times)</p>

<p style="margin-left: 40px">Remaining telomere length after cell divisions : 5,000 nucleotides</p>

<p>---------------------------------------------------------------------------------------</p>

<p style="margin-left: 40px">Telomere length shortened by cell divisions : <strong>10,000 nucleotides</strong></p>

<p style="margin-left: 40px">&nbsp;</p>

<p style="margin-left: 40px">Somatic cells usually divide up <strong>to 50~70 times</strong></p>

<p>&nbsp;</p>

<p>Therefore, 10,000 nucleotides / 50~70 times =<strong> 150~200 nucleotides </strong>are shortened in each cell division.</p>

<p>&nbsp;</p>

<p>&nbsp;</p>

<p><strong>&lt;Presentation by&nbsp;Sungbin and&nbsp;Juhyeon : Host transmission of a MERS CoV genome&gt;</strong></p>

<p>&nbsp;<strong>My question</strong></p>

<p>-Why did they select a MERS CoV genome, even though camel is not familiar to Korean?</p>

<p style="margin-left: 40px">MERS CoV genome is only in humans and camel, and it is infected to Korean.</p>

<p>&nbsp;</p>

<p>-Why did they divide three variations: time, host, and region?</p>

<p style="margin-left: 40px">It is by isolation from GB data.</p>

<p>&nbsp;</p>

<p>*ORF : open reading frame</p>

<p>&nbsp;</p>

<p>&nbsp;</p>

<p><strong>&lt;Lecture by Jong&gt;</strong></p>

<p>-Aging is a disease?</p>

<p style="margin-left: 40px">I think aging is a disease.</p>

<p style="margin-left: 80px">&nbsp;</p>

<p>-What is a difference between aging and cancer?</p>

<p style="margin-left: 40px">Aging is already programmed, but cancer is accident.</p>

<p>&nbsp;</p>

<p>-Why do we age?</p>

<p>&nbsp;</p>

<p>-A study of Aging by bioinformatics</p>

<p style="margin-left: 40px">Comparison of young genome and old genome</p>

<p style="margin-left: 40px">Genome analysis of people who live longer more than 100 years</p>

<p style="margin-left: 40px">reversing epigenetic change by using CRISPR-Cas9</p>

<p style="margin-left: 40px">Female diver(해녀) have a certain bone structure.</p>

<p>&nbsp;</p>

<p>-Genomics &amp; Epigenomics</p>

<p>&nbsp;</p>

<p>*pneumonia: 폐렴</p>