View source for 05.13 class

<p>bioinformatics is about mapping - but you have to choose the right parameter!<br />
old map is not accurate<br />
however it helps people to explore</p>

<p>what is life?<br />
life is a set of switches (professor&#39;s thought)</p>

<p>bioinformatics is the study of compelxity (thigs with a lot of #s, big data)<br />
three fundamental elements in bioinformatics : energy, information in time</p>

<p>6 domains of bioinformatics<br />
sequence, structure, expression,interaction, function, network</p>

<p>2 (paired) is the most important for the DNA structure - Creek &amp; Watson<br />
(Linus Pauling suggested tri-helix structure)</p>

<p>Alan Turing&nbsp;- he proposed that the world can be computed</p>

<p>representation of data - sequence, structure, expression, &quot;pathways&quot;(directional), function, network</p>

<p>you have to memorize all amino acids!<br />
species-genus-family-(superfamily)-order-class-phlym-kingdom</p>

<p>mass production of data (high throughput technology)<br />
-about 2004, human genome project finished<br />
DNA/RNA microarray<br />
structural genomics<br />
proteomics (mass spectrometry)<br />
interactomics (Y2H(yeast&nbsp;two hybridize), protein chips based)<br />
sequencing (5 minutes for sequencing whole human genome)</p>