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<h2> Protein Pattern Analysis</h2>
<h2>Motif, Pattern, ProfileProfiling, Signature</h2>
<p>Sequence motif - amino acid sequence pattern that is widespread and has a biological significance</p> <p>Cf) Structural motif - connectivity between secondary structure elements<sup>1) </sup>- The simplest structural motif is a helical bundle</p> <p><a href="http://www.proteinstructures.com/Structure/Structure/protein-motifs_files/helix-bundle.jpg"><img alt="" src="http://www.proteinstructures.com/Structure/Structure/protein-motifs_files/helix-bundle.jpg" style="height:121px; width:161px" /></a>(<a href="http://www.proteinstructures.com/Structure/Structure/protein-motifs.html">http://www.proteinstructures.com/Structure/Structure/protein-motifs.html</a>)</p> <p>Pattern - Characters that appear in common in one protein family</p> <p>two or more patterns are associated with a single motif <sup>2)</sup></p> <p>Protein Profiling - the detection of the character or quantity of specific sets of proteins</p> <p>Signature - a part of whole pattern. Short diagnostic pattern that we can find the character of specific protein</p>
<h2>1. PROSITE (prosite.expasy.org)</h2>
<p><sup>13)</sup>A protein database which consists of the protein families, domains, functional sites, amino acid patterns and profiles.</p>
<p>They are manually curated by a team of Swiss Institute of Bioinformatics</p>
<p>*** All these websites are listed in the book called 'Bioinformatics with bioperl' authored by Young-chang Kim</p>
<p>1) <a href="http://www.proteinstructures.com/Structure/Structure/protein-motifs.html">http://www.proteinstructures.com/Structure/Structure/protein-motifs.html</a></p> <p>2) <a href="https://en.wikipedia.org/wiki/Sequence_motif">https://en.wikipedia.org/wiki/Sequence_motif</a></p> <p>3) <a href="https://en.wikipedia.org/wiki/PROSITE">https://en.wikipedia.org/wiki/PROSITE</a></p>
<p> </p>
