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From Biolecture.org
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<p>Koreans have high oppotunity to have colon cancer. if westernization dietary habits is reason for the high rate of colon cancer, why korean have more high rate than western people? </p>
<p>In some european, Jews of Eastern European descent (Ashkenazi Jews) have one of the highest colorectal cancer risks of any ethnic group in the world. Several gene mutations leading to an increased risk of colorectal cancer have been found in this group. The most common of these gene changes, called the <em>I1307K APC mutation</em>,</p>
<p>(refered from: American cancer society URL: http://www.cancer.org/cancer/colonandrectumcancer/detailedguide/colorectal-cancer-risk-factors)</p>
<p>So i tried to found the specific mutation in korean. </p>
<p>First i try to find important genes in colon cancer</p>
<p><img alt="" src="/ckfinder/userfiles/images/%EA%B7%B8%EB%A6%BC2.jpg" style="height:646px; width:1078px" />'</p>
<p>Referred from Narayan S, et al. Role of APC and DNA mismatch repair genes in the development of colorectal cancers. Mol Cancer. 2:41. 2003 Dec 12</p>
<p>In this pathway of colon cancer the <em>APC </em>gene have critical role and ~55% of colon cancer patient have mutation of this gene. so i find to case study of korean and find interesting things. </p>
<p><img alt="" src="/ckfinder/userfiles/images/%EA%B7%B8%EB%A6%BC3.png" style="height:570px; width:797px" /></p>
<p>Referred from Sang Hyuk Cho, et al：APC Mutation Spectra in Sporadic Colon Cancer Tissue among Korean. Annals of Surgical Treatment and Research. 76(3), 2009.3, 159-167</p>
<p>In Korean colon cancer patien the <em>APC </em>gene exon 3 mutation is more than half of patient. Studies before this paper the APC gene has mutation almost in exon 15 because in exon 15 is long and have MCR(Mutation Clustering Region). So this can be interesting topic for studying colon cancer specific in korean</p>
