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<h2>Only 2 % of human genome encodes protein and the other 98% controls gene expression by epigenetic mechanism.</h2>
<h2>Application</h2> <p>1. Neurological defects could be recovered by correctly recognizing DNA methylation pettern<sup>4)</sup></p> <p>Rett syndrome, one of the severe mental retardation diseases, is mostly caused by <em>MeCP2</em> mutation</p> <p>MeCP2 is a protein that decodes DNA methylated regions. If <em>MeCP2 </em>is mutated, we cannot decode these epigenetic codes.</p> <p>There is a vidio <sup>5) </sup>about recovering mentar redardation by activating normal <em>MeCP2</em> gene using certain chemacals in a mouce.</p> <p>It suggests that we could develop therapies for diverse mental development disorders by studying epigenetics in the future.</p> <p><iframe allowfullscreen="" frameborder="0" height="480" src="//www.youtube.com/embed/RyAvKGmAElQ" width="640"></iframe></p>
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<p>3) Nan, Xinsheng, et al. "Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex." <em>Nature</em> 393.6683 (1998): 386-389.</p>
<p>4) Guy, Jacky, et al. "Reversal of neurological defects in a mouse model of Rett syndrome." <em>Science</em> 315.5815 (2007): 1143-1147.</p>
<p>5) https://www.youtube.com/watch?v=RyAvKGmAElQ&feature=related</p>
